Association between dietary meat consumption and incident type 2 diabetes: The EPIC-InterAct study

B. Bendinelli, D. Palli, G. Masala, S. J. Sharp, M. B. Schulze, M. Guevara, D. L. van der A, F. Sera, P. Amiano, B. Balkau, A. Barricarte, H. Boeing, F. L. Crowe, C. C. Dahm, G. Dalmeijer, B. de Lauzon-Guillain, R. Egeberg, G. Fagherazzi, P. W. Franks, V. KroghJ. M. Huerta, P. Jakszyn, K. T. Khaw, K. Li, A. Mattiello, P. M. Nilsson, K. Overvad, F. Ricceri, L. Rodríguez-Suárez, O. Rolandsson, M. J. Sánchez, N. Slimani, I. Sluijs, A. M W Spijkerman, B. Teucher, A. Tjonneland, R. Tumino, S. W. van den Berg, N. G. Forouhi, C. Langenberg, E. J M Feskens, E. Riboli, N. J. Wareham

Research output: Contribution to journalArticle

Abstract

Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

Original languageEnglish
Pages (from-to)47-59
Number of pages13
JournalDiabetologia
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Meat
Type 2 Diabetes Mellitus
Neoplasms
Poultry
Cohort Studies
Multivariate Analysis
Iron
Regression Analysis
Prospective Studies
Diet
Red Meat

Keywords

  • Case-cohort study
  • Diet
  • Meat
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Bendinelli, B., Palli, D., Masala, G., Sharp, S. J., Schulze, M. B., Guevara, M., ... Wareham, N. J. (2013). Association between dietary meat consumption and incident type 2 diabetes: The EPIC-InterAct study. Diabetologia, 56(1), 47-59. https://doi.org/10.1007/s00125-012-2718-7

Association between dietary meat consumption and incident type 2 diabetes : The EPIC-InterAct study. / Bendinelli, B.; Palli, D.; Masala, G.; Sharp, S. J.; Schulze, M. B.; Guevara, M.; van der A, D. L.; Sera, F.; Amiano, P.; Balkau, B.; Barricarte, A.; Boeing, H.; Crowe, F. L.; Dahm, C. C.; Dalmeijer, G.; de Lauzon-Guillain, B.; Egeberg, R.; Fagherazzi, G.; Franks, P. W.; Krogh, V.; Huerta, J. M.; Jakszyn, P.; Khaw, K. T.; Li, K.; Mattiello, A.; Nilsson, P. M.; Overvad, K.; Ricceri, F.; Rodríguez-Suárez, L.; Rolandsson, O.; Sánchez, M. J.; Slimani, N.; Sluijs, I.; Spijkerman, A. M W; Teucher, B.; Tjonneland, A.; Tumino, R.; van den Berg, S. W.; Forouhi, N. G.; Langenberg, C.; Feskens, E. J M; Riboli, E.; Wareham, N. J.

In: Diabetologia, Vol. 56, No. 1, 01.2013, p. 47-59.

Research output: Contribution to journalArticle

Bendinelli, B, Palli, D, Masala, G, Sharp, SJ, Schulze, MB, Guevara, M, van der A, DL, Sera, F, Amiano, P, Balkau, B, Barricarte, A, Boeing, H, Crowe, FL, Dahm, CC, Dalmeijer, G, de Lauzon-Guillain, B, Egeberg, R, Fagherazzi, G, Franks, PW, Krogh, V, Huerta, JM, Jakszyn, P, Khaw, KT, Li, K, Mattiello, A, Nilsson, PM, Overvad, K, Ricceri, F, Rodríguez-Suárez, L, Rolandsson, O, Sánchez, MJ, Slimani, N, Sluijs, I, Spijkerman, AMW, Teucher, B, Tjonneland, A, Tumino, R, van den Berg, SW, Forouhi, NG, Langenberg, C, Feskens, EJM, Riboli, E & Wareham, NJ 2013, 'Association between dietary meat consumption and incident type 2 diabetes: The EPIC-InterAct study', Diabetologia, vol. 56, no. 1, pp. 47-59. https://doi.org/10.1007/s00125-012-2718-7
Bendinelli, B. ; Palli, D. ; Masala, G. ; Sharp, S. J. ; Schulze, M. B. ; Guevara, M. ; van der A, D. L. ; Sera, F. ; Amiano, P. ; Balkau, B. ; Barricarte, A. ; Boeing, H. ; Crowe, F. L. ; Dahm, C. C. ; Dalmeijer, G. ; de Lauzon-Guillain, B. ; Egeberg, R. ; Fagherazzi, G. ; Franks, P. W. ; Krogh, V. ; Huerta, J. M. ; Jakszyn, P. ; Khaw, K. T. ; Li, K. ; Mattiello, A. ; Nilsson, P. M. ; Overvad, K. ; Ricceri, F. ; Rodríguez-Suárez, L. ; Rolandsson, O. ; Sánchez, M. J. ; Slimani, N. ; Sluijs, I. ; Spijkerman, A. M W ; Teucher, B. ; Tjonneland, A. ; Tumino, R. ; van den Berg, S. W. ; Forouhi, N. G. ; Langenberg, C. ; Feskens, E. J M ; Riboli, E. ; Wareham, N. J. / Association between dietary meat consumption and incident type 2 diabetes : The EPIC-InterAct study. In: Diabetologia. 2013 ; Vol. 56, No. 1. pp. 47-59.
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T1 - Association between dietary meat consumption and incident type 2 diabetes

T2 - The EPIC-InterAct study

AU - Bendinelli, B.

AU - Palli, D.

AU - Masala, G.

AU - Sharp, S. J.

AU - Schulze, M. B.

AU - Guevara, M.

AU - van der A, D. L.

AU - Sera, F.

AU - Amiano, P.

AU - Balkau, B.

AU - Barricarte, A.

AU - Boeing, H.

AU - Crowe, F. L.

AU - Dahm, C. C.

AU - Dalmeijer, G.

AU - de Lauzon-Guillain, B.

AU - Egeberg, R.

AU - Fagherazzi, G.

AU - Franks, P. W.

AU - Krogh, V.

AU - Huerta, J. M.

AU - Jakszyn, P.

AU - Khaw, K. T.

AU - Li, K.

AU - Mattiello, A.

AU - Nilsson, P. M.

AU - Overvad, K.

AU - Ricceri, F.

AU - Rodríguez-Suárez, L.

AU - Rolandsson, O.

AU - Sánchez, M. J.

AU - Slimani, N.

AU - Sluijs, I.

AU - Spijkerman, A. M W

AU - Teucher, B.

AU - Tjonneland, A.

AU - Tumino, R.

AU - van den Berg, S. W.

AU - Forouhi, N. G.

AU - Langenberg, C.

AU - Feskens, E. J M

AU - Riboli, E.

AU - Wareham, N. J.

PY - 2013/1

Y1 - 2013/1

N2 - Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

AB - Aims/hypothesis: A diet rich in meat has been reported to contribute to the risk of type 2 diabetes. The present study aims to investigate the association between meat consumption and incident type 2 diabetes in the EPIC-InterAct study, a large prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: During 11.7 years of follow-up, 12,403 incident cases of type 2 diabetes were identified among 340,234 adults from eight European countries. A centre-stratified random subsample of 16,835 individuals was selected in order to perform a case-cohort design. Prentice-weighted Cox regression analyses were used to estimate HR and 95% CI for incident diabetes according to meat consumption. Results: Overall, multivariate analyses showed significant positive associations with incident type 2 diabetes for increasing consumption of total meat (50 g increments: HR 1.08; 95% CI 1.05, 1.12), red meat (HR 1.08; 95% CI 1.03, 1.13) and processed meat (HR 1.12; 95% CI 1.05, 1.19), and a borderline positive association with meat iron intake. Effect modifications by sex and class of BMI were observed. In men, the results of the overall analyses were confirmed. In women, the association with total and red meat persisted, although attenuated, while an association with poultry consumption also emerged (HR 1.20; 95% CI 1.07, 1.34). These associations were not evident among obese participants. Conclusions/interpretation: This prospective study confirms a positive association between high consumption of total and red meat and incident type 2 diabetes in a large cohort of European adults.

KW - Case-cohort study

KW - Diet

KW - Meat

KW - Type 2 diabetes

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