Association between frequent cardiac resynchronization therapy optimization and long-term clinical response: A post hoc analysis of the Clinical Evaluation on Advanced Resynchronization (CLEAR) pilot study

Peter Paul Delnoy, Philippe Ritter, Herbert Naegele, Serafino Orazi, Hanna Szwed, Igor Zupan, Kinga Goscinska-Bis, Frederic Anselme, Maria Martino, Luigi Padeletti

Research output: Contribution to journalArticle


AimsThe long-term clinical value of the optimization of atrioventricular (AVD) and interventricular (VVD) delays in cardiac resynchronization therapy (CRT) remains controversial. We studied retrospectively the association between the frequency of AVD and VVD optimization and 1-year clinical outcomes in the 199 CRT patients who completed the Clinical Evaluation on Advanced Resynchronization study.Methods and resultsFrom the 199 patients assigned to CRT-pacemaker (CRT-P) (New York Heart Association, NYHA, class III/IV, left ventricular ejection fraction

Original languageEnglish
Pages (from-to)1174-1181
Number of pages8
Issue number8
Publication statusPublished - Aug 2013



  • Atrioventricular delay
  • Cardiac resynchronization therapy optimization frequency
  • Echocardiography
  • Interventricular delay
  • Long-term clinical response
  • SonR™

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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