Association Between Gait Speed With Mortality, Cardiovascular Disease and Cancer: A Systematic Review and Meta-analysis of Prospective Cohort Studies

Nicola Veronese, Brendon Stubbs, Stefano Volpato, Giovanni Zuliani, Stefania Maggi, Matteo Cesari, Darren M. Lipnicki, Lee Smith, Patricia Schofield, Joseph Firth, Davy Vancampfort, Ai Koyanagi, Alberto Pilotto, Emanuele Cereda

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Abstract

Objectives: Slow gait speed may be associated with premature mortality, cardiovascular disease (CVD), and cancer, although a comprehensive meta-analysis is lacking. In this systematic review and meta-analysis, we explored potential associations between gait speed and mortality, incident CVD, and cancer. Design: A systematic search in major databases was undertaken from inception until March 15, 2018 for prospective cohort studies reporting data on gait speed and mortality, incident CVD, and cancer. Setting and Participants: All available. Measures: The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs), based on the model with the maximum number of covariates for each study between gait speed (categorized as decrease in 0.1 m/s) and mortality, incident CVD, and cancer, were meta-analyzed with a random effects model. Results: Among 7026 articles, 44 articles corresponding to 48 independent cohorts were eligible. The studies followed up on a total of 101,945 participants (mean age 72.2 years; 55% women) for a median of 5.4 years. After adjusting for a median of 9 potential confounders and the presence of publication bias, each reduction of 0.1 m/s in gait speed was associated with a 14% increased risk of earlier mortality (45 studies; HR = 1.12, 95% CI: 1.09-1.14; I2 = 90%) and 8% increased risk of CVD (13 studies; HR = 1.08, 95% CI: 1.03-1.13; I2 = 81%), but no relationship with cancer was observed (HR = 1.00, 95% CI: 0.97-1.04; I2 = 15%). Conclusion/implications: Slow gait speed may be a predictor of mortality and CVD in older adults. Because gait speed is a quick and inexpensive measure to obtain, our study suggests that it should be routinely used and may help identify people at risk of premature mortality and CVD.

Original languageEnglish
Pages (from-to)981-988.e7
JournalJournal of the American Medical Directors Association
Volume19
Issue number11
DOIs
Publication statusPublished - 2018

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Keywords

  • cancer
  • cardiovascular disease
  • Gait speed
  • meta-analysis
  • mortality

ASJC Scopus subject areas

  • Nursing(all)
  • Health Policy

Cite this

Veronese, N., Stubbs, B., Volpato, S., Zuliani, G., Maggi, S., Cesari, M., Lipnicki, D. M., Smith, L., Schofield, P., Firth, J., Vancampfort, D., Koyanagi, A., Pilotto, A., & Cereda, E. (2018). Association Between Gait Speed With Mortality, Cardiovascular Disease and Cancer: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Journal of the American Medical Directors Association, 19(11), 981-988.e7. https://doi.org/10.1016/j.jamda.2018.06.007