Abstract
Background: Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not previously been compared. Objective: The aim of this study was to investigate which of three different equations for estimating renal function (Cockcroft-Gault [CG], Modification of Diet in Renal Disease [MDRD] and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) was the most effective at predicting incident hADRs. Methods: This multicentre study had an observational design and included 81 acute-care general (internal) or geriatric medicine wards in academic hospitals throughout Italy. Our series consisted of 10 442 hospitalized patients with a mean ± SD age of 70.2 ± 14.9 years enrolled in the GIFA study. The main outcome measures were incident ADRs during hospital stay. Data on these were collected and classified as hADRs or ADRs to liposoluble drugs (lADRs). Patients were grouped according to their eGFR (mL/min/1.73m2) or eCCr (mL/min): ≥90, 60-89.9, 45-59.9, 30-44.9 or 2 calculated using CKD-EPI (60-89.9: hazard ratio [HR] = 1.07 [95% CI 0.70, 1.72]; 45-59.9: HR= 1.62 [95%CI 1.0, 2.69]; 30-44.9: HR= 2.13 [95%CI 1.24, 3.64];
| Original language | English |
|---|---|
| Pages (from-to) | 379-390 |
| Number of pages | 12 |
| Journal | Drugs and Aging |
| Volume | 28 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- Adverse-drug-reactions
- Elderly
- Renal-function.
ASJC Scopus subject areas
- Pharmacology (medical)
- Geriatrics and Gerontology
Cite this
Association between glomerular filtration rate and adverse drug reactions in elderly hospitalized patients : The role of the estimating equation. / Corsonello, Andrea; Pedone, Claudio; Lattanzio, Fabrizia; Onder, Graziano; Antonelli Incalzi, Raffaele.
In: Drugs and Aging, Vol. 28, No. 5, 2011, p. 379-390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between glomerular filtration rate and adverse drug reactions in elderly hospitalized patients
T2 - The role of the estimating equation
AU - Corsonello, Andrea
AU - Pedone, Claudio
AU - Lattanzio, Fabrizia
AU - Onder, Graziano
AU - Antonelli Incalzi, Raffaele
PY - 2011
Y1 - 2011
N2 - Background: Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not previously been compared. Objective: The aim of this study was to investigate which of three different equations for estimating renal function (Cockcroft-Gault [CG], Modification of Diet in Renal Disease [MDRD] and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) was the most effective at predicting incident hADRs. Methods: This multicentre study had an observational design and included 81 acute-care general (internal) or geriatric medicine wards in academic hospitals throughout Italy. Our series consisted of 10 442 hospitalized patients with a mean ± SD age of 70.2 ± 14.9 years enrolled in the GIFA study. The main outcome measures were incident ADRs during hospital stay. Data on these were collected and classified as hADRs or ADRs to liposoluble drugs (lADRs). Patients were grouped according to their eGFR (mL/min/1.73m2) or eCCr (mL/min): ≥90, 60-89.9, 45-59.9, 30-44.9 or 2 calculated using CKD-EPI (60-89.9: hazard ratio [HR] = 1.07 [95% CI 0.70, 1.72]; 45-59.9: HR= 1.62 [95%CI 1.0, 2.69]; 30-44.9: HR= 2.13 [95%CI 1.24, 3.64];
AB - Background: Reduced renal function increases the risk of adverse drug reactions (ADRs) to hydrosoluble drugs (hADRs). However, the ability of different equations to calculate estimated glomerular filtration rate (eGFR) or estimated creatinine clearance (eCCr) and thereby predict the risk of developing hADRs has not previously been compared. Objective: The aim of this study was to investigate which of three different equations for estimating renal function (Cockcroft-Gault [CG], Modification of Diet in Renal Disease [MDRD] and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) was the most effective at predicting incident hADRs. Methods: This multicentre study had an observational design and included 81 acute-care general (internal) or geriatric medicine wards in academic hospitals throughout Italy. Our series consisted of 10 442 hospitalized patients with a mean ± SD age of 70.2 ± 14.9 years enrolled in the GIFA study. The main outcome measures were incident ADRs during hospital stay. Data on these were collected and classified as hADRs or ADRs to liposoluble drugs (lADRs). Patients were grouped according to their eGFR (mL/min/1.73m2) or eCCr (mL/min): ≥90, 60-89.9, 45-59.9, 30-44.9 or 2 calculated using CKD-EPI (60-89.9: hazard ratio [HR] = 1.07 [95% CI 0.70, 1.72]; 45-59.9: HR= 1.62 [95%CI 1.0, 2.69]; 30-44.9: HR= 2.13 [95%CI 1.24, 3.64];
KW - Adverse-drug-reactions
KW - Elderly
KW - Renal-function.
UR - http://www.scopus.com/inward/record.url?scp=79955683771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955683771&partnerID=8YFLogxK
U2 - 10.2165/11588280-000000000-00000
DO - 10.2165/11588280-000000000-00000
M3 - Article
C2 - 21542660
AN - SCOPUS:79955683771
VL - 28
SP - 379
EP - 390
JO - Drugs and Aging
JF - Drugs and Aging
SN - 1170-229X
IS - 5
ER -