TY - JOUR
T1 - Association between hepatitis C and B viruses and head and neck squamous cell carcinoma
AU - Donà, Sara
AU - Borsetto, Daniele
AU - Fussey, Jonathan
AU - Biscaro, Valeria
AU - Vian, Elisa
AU - Spinato, Giacomo
AU - Menegaldo, Anna
AU - Da Mosto, Maria Cristina
AU - Rigoli, Roberto
AU - Polesel, Jerry
AU - Boscolo-Rizzo, Paolo
PY - 2019/12
Y1 - 2019/12
N2 - Background: Hepatitis B and C viruses are known to be carcinogenic and have been associated with the development of non-Hodgkin's lymphoma as well as hepatocellular carcinoma. The incidence of head and neck cancer is increasing worldwide, and early diagnosis is vital in order to achieve good oncological outcomes. Objectives: To investigate the association between chronic hepatitis B and C infection, and head and neck squamous cell carcinoma (HNSCC). Study design: We performed a retrospective case control study with 774 head and neck squamous cell carcinoma (HNSCC) patients undergoing treatment, and 1518 cancer-free controls undergoing hernia surgery. Hepatitis B and C serologies were tested prior to treatment, and cases and controls were age- and sex-matched before analysing rates of infection. Results: HNSCC patients were more likely than controls to have evidence of chronic hepatitis B (OR = 2.76; CI 95 %, 1.64–4.64) and hepatitis C (OR = 2.59; 95 % CI, 1.46–4.60) infection. No substantial association was found between hepatitis B and C infection and other known risk factors for head and neck cancer. Conclusions: These findings suggest a positive association between both hepatitis B and hepatitis C chronic infection, and HNSCC. More work is needed to establish a causal role, however an awareness of the possibility of increased risk of HNSCC may lead to earlier diagnosis and better outcomes in patients with hepatitis B and C.
AB - Background: Hepatitis B and C viruses are known to be carcinogenic and have been associated with the development of non-Hodgkin's lymphoma as well as hepatocellular carcinoma. The incidence of head and neck cancer is increasing worldwide, and early diagnosis is vital in order to achieve good oncological outcomes. Objectives: To investigate the association between chronic hepatitis B and C infection, and head and neck squamous cell carcinoma (HNSCC). Study design: We performed a retrospective case control study with 774 head and neck squamous cell carcinoma (HNSCC) patients undergoing treatment, and 1518 cancer-free controls undergoing hernia surgery. Hepatitis B and C serologies were tested prior to treatment, and cases and controls were age- and sex-matched before analysing rates of infection. Results: HNSCC patients were more likely than controls to have evidence of chronic hepatitis B (OR = 2.76; CI 95 %, 1.64–4.64) and hepatitis C (OR = 2.59; 95 % CI, 1.46–4.60) infection. No substantial association was found between hepatitis B and C infection and other known risk factors for head and neck cancer. Conclusions: These findings suggest a positive association between both hepatitis B and hepatitis C chronic infection, and HNSCC. More work is needed to establish a causal role, however an awareness of the possibility of increased risk of HNSCC may lead to earlier diagnosis and better outcomes in patients with hepatitis B and C.
KW - Case-control study
KW - Epidemiology
KW - Head and neck cancer
KW - Hepatitis B infection
KW - Hepatitis C infection
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U2 - 10.1016/j.jcv.2019.104209
DO - 10.1016/j.jcv.2019.104209
M3 - Article
C2 - 31711028
AN - SCOPUS:85074537259
VL - 121
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
M1 - 104209
ER -