Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients

Massimo Iacoviello, Francesca Di Serio, Caterina Rizzo, Marta Leone, Dario Grande, Pietro Guida, Margherita Ilaria Gioia, Giuseppe Parisi, Tiziana Leopizzi, Pasquale Caldarola, Marco Matteo Ciccone, Loreto Gesualdo

Research output: Contribution to journalArticle

Abstract

Aim: The aim of the study was to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients. Methods & results: This prospective study of 260 chronic heart failure patients showed that Gal-3 was associated with 1-year worsening of renal function both in univariate (odds ratio: 1.12; 95% CI: 1.06-1.18; p < 0.001) and in forward stepwise multivariate (odds ratio: 1.09; 95% CI: 1.03-1.15; p = 0.004) logistic regression analyses. Moreover, high Gal-3 levels at baseline were associated with a progressive decline in the estimated glomerular filtration rate. Conclusion: Gal-3 is a biomarker associated with the progression of renal function decline thus further supporting its possible usefulness in predicting cardiorenal syndrome progression.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalBiomarkers in Medicine
Volume13
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • cardiorenal syndrome
  • chronic heart failure
  • Gal-3
  • worsening of renal function

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Iacoviello, M., Di Serio, F., Rizzo, C., Leone, M., Grande, D., Guida, P., Gioia, M. I., Parisi, G., Leopizzi, T., Caldarola, P., Ciccone, M. M., & Gesualdo, L. (2019). Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients. Biomarkers in Medicine, 13(9), 707-713. https://doi.org/10.2217/bmm-2018-0349