Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients

Massimo Iacoviello; Francesca Di Serio; Caterina Rizzo; Marta Leone; Dario Grande; Pietro Guida; Margherita Ilaria Gioia; Giuseppe Parisi; Tiziana Leopizzi; Pasquale Caldarola; Marco Matteo Ciccone; Loreto Gesualdo

doi:10.2217/bmm-2018-0349

Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients

Massimo Iacoviello, Francesca Di Serio, Caterina Rizzo, Marta Leone, Dario Grande, Pietro Guida, Margherita Ilaria Gioia, Giuseppe Parisi, Tiziana Leopizzi, Pasquale Caldarola, Marco Matteo Ciccone, Loreto Gesualdo

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: The aim of the study was to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients. Methods & results: This prospective study of 260 chronic heart failure patients showed that Gal-3 was associated with 1-year worsening of renal function both in univariate (odds ratio: 1.12; 95% CI: 1.06-1.18; p < 0.001) and in forward stepwise multivariate (odds ratio: 1.09; 95% CI: 1.03-1.15; p = 0.004) logistic regression analyses. Moreover, high Gal-3 levels at baseline were associated with a progressive decline in the estimated glomerular filtration rate. Conclusion: Gal-3 is a biomarker associated with the progression of renal function decline thus further supporting its possible usefulness in predicting cardiorenal syndrome progression.

Original language	English
Pages (from-to)	707-713
Number of pages	7
Journal	Biomarkers in Medicine
Volume	13
Issue number	9
DOIs	https://doi.org/10.2217/bmm-2018-0349
Publication status	Published - Jan 1 2019

Keywords

cardiorenal syndrome
chronic heart failure
Gal-3
worsening of renal function

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients. / Iacoviello, Massimo; Di Serio, Francesca; Rizzo, Caterina ; Leone, Marta; Grande, Dario; Guida, Pietro; Gioia, Margherita Ilaria; Parisi, Giuseppe; Leopizzi, Tiziana; Caldarola, Pasquale; Ciccone, Marco Matteo; Gesualdo, Loreto.

In: Biomarkers in Medicine, Vol. 13, No. 9, 01.01.2019, p. 707-713.

Research output: Contribution to journal › Article › peer-review

Iacoviello, Massimo ; Di Serio, Francesca ; Rizzo, Caterina ; Leone, Marta ; Grande, Dario ; Guida, Pietro ; Gioia, Margherita Ilaria ; Parisi, Giuseppe ; Leopizzi, Tiziana ; Caldarola, Pasquale ; Ciccone, Marco Matteo ; Gesualdo, Loreto. / Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients. In: Biomarkers in Medicine. 2019 ; Vol. 13, No. 9. pp. 707-713.

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abstract = "Aim: The aim of the study was to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients. Methods & results: This prospective study of 260 chronic heart failure patients showed that Gal-3 was associated with 1-year worsening of renal function both in univariate (odds ratio: 1.12; 95% CI: 1.06-1.18; p < 0.001) and in forward stepwise multivariate (odds ratio: 1.09; 95% CI: 1.03-1.15; p = 0.004) logistic regression analyses. Moreover, high Gal-3 levels at baseline were associated with a progressive decline in the estimated glomerular filtration rate. Conclusion: Gal-3 is a biomarker associated with the progression of renal function decline thus further supporting its possible usefulness in predicting cardiorenal syndrome progression.",

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AU - Grande, Dario

AU - Guida, Pietro

AU - Gioia, Margherita Ilaria

AU - Parisi, Giuseppe

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AU - Ciccone, Marco Matteo

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