TY - JOUR
T1 - Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients
AU - Iacoviello, Massimo
AU - Di Serio, Francesca
AU - Rizzo, Caterina
AU - Leone, Marta
AU - Grande, Dario
AU - Guida, Pietro
AU - Gioia, Margherita Ilaria
AU - Parisi, Giuseppe
AU - Leopizzi, Tiziana
AU - Caldarola, Pasquale
AU - Ciccone, Marco Matteo
AU - Gesualdo, Loreto
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aim: The aim of the study was to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients. Methods & results: This prospective study of 260 chronic heart failure patients showed that Gal-3 was associated with 1-year worsening of renal function both in univariate (odds ratio: 1.12; 95% CI: 1.06-1.18; p < 0.001) and in forward stepwise multivariate (odds ratio: 1.09; 95% CI: 1.03-1.15; p = 0.004) logistic regression analyses. Moreover, high Gal-3 levels at baseline were associated with a progressive decline in the estimated glomerular filtration rate. Conclusion: Gal-3 is a biomarker associated with the progression of renal function decline thus further supporting its possible usefulness in predicting cardiorenal syndrome progression.
AB - Aim: The aim of the study was to evaluate the association between Gal-3 serum levels and the progression of renal dysfunction in chronic heart failure outpatients. Methods & results: This prospective study of 260 chronic heart failure patients showed that Gal-3 was associated with 1-year worsening of renal function both in univariate (odds ratio: 1.12; 95% CI: 1.06-1.18; p < 0.001) and in forward stepwise multivariate (odds ratio: 1.09; 95% CI: 1.03-1.15; p = 0.004) logistic regression analyses. Moreover, high Gal-3 levels at baseline were associated with a progressive decline in the estimated glomerular filtration rate. Conclusion: Gal-3 is a biomarker associated with the progression of renal function decline thus further supporting its possible usefulness in predicting cardiorenal syndrome progression.
KW - cardiorenal syndrome
KW - chronic heart failure
KW - Gal-3
KW - worsening of renal function
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U2 - 10.2217/bmm-2018-0349
DO - 10.2217/bmm-2018-0349
M3 - Article
C2 - 31157541
AN - SCOPUS:85069438683
VL - 13
SP - 707
EP - 713
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 9
ER -