Association between Hippocampal Shape, Neuroinflammation, and Cognitive Decline in Alzheimer's Disease

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Abstract

Background: Alzheimer's disease (AD) is a neurodegenerative condition characterized by memory impairment and general decrease in cognitive functions and daily living competences, that leads to a complete loss of autonomy. The pathogenesis of AD is characterized by the deposition of amyloid-β plaques (Aβ plaques) and neurofibrillary tangles, initially involving cortical and hippocampal structures, and neuroinflammation. To date, no studies have investigated the topological association between neuroinflammation and hippocampal shape in AD. Objective: The aim of the present study is to assess the association between hippocampal shape, cognitive profile, and neuroinflammation in a group of AD patients in the mild stage of the disease. Methods: Thirty-one patients with typical onset AD (mild stage) underwent MRI examination (1.5T scanner); hippocampal structures were segmented using a vertex-wise analysis (FSL-FIRST). Immune parameters were evaluated on peripheral blood mononuclear cells by flow-cytometry. Correlation analyses were performed between hippocampal shape and both cognitive profile (ADAS-Cog and MMSE scores), and neuro-inflammatory variables (i.e., circulating monocytes, cytokines). Results: Statistically significant correlations (p < 0.05 FWE) between right hippocampal shape and cognitive measurements and between left hippocampal shape and inflammatory indices were detected. The hippocampal field mostly involved was the lateral portion of bilateral hippocampi, mainly overlapping with Cornu Ammonis, extending along the entire longitudinal axis. Conclusions: A topological relationship between hippocampal atrophy and both cognitive profile and neuroinflammation is found; the association with neuroinflammatory indices is in line with the pattern of AD-Associated neuronal death, whereas the association with cognitive test might account for residual cognitive functions.

Original languageEnglish
Pages (from-to)1131-1144
Number of pages14
JournalJournal of Alzheimer's Disease
Volume66
Issue number3
DOIs
Publication statusPublished - Jan 1 2018

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Alzheimer Disease
Cognition
Hippocampus
Neurofibrillary Tangles
Amyloid Plaques
Mental Competency
Atrophy
Cognitive Dysfunction
Monocytes
Blood Cells
Flow Cytometry
Cytokines

Keywords

  • Alzheimer's disease
  • brain
  • flow cytometry
  • hippocampus
  • inflammation
  • Magnetic Resonance Imaging (MRI)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

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title = "Association between Hippocampal Shape, Neuroinflammation, and Cognitive Decline in Alzheimer's Disease",
abstract = "Background: Alzheimer's disease (AD) is a neurodegenerative condition characterized by memory impairment and general decrease in cognitive functions and daily living competences, that leads to a complete loss of autonomy. The pathogenesis of AD is characterized by the deposition of amyloid-β plaques (Aβ plaques) and neurofibrillary tangles, initially involving cortical and hippocampal structures, and neuroinflammation. To date, no studies have investigated the topological association between neuroinflammation and hippocampal shape in AD. Objective: The aim of the present study is to assess the association between hippocampal shape, cognitive profile, and neuroinflammation in a group of AD patients in the mild stage of the disease. Methods: Thirty-one patients with typical onset AD (mild stage) underwent MRI examination (1.5T scanner); hippocampal structures were segmented using a vertex-wise analysis (FSL-FIRST). Immune parameters were evaluated on peripheral blood mononuclear cells by flow-cytometry. Correlation analyses were performed between hippocampal shape and both cognitive profile (ADAS-Cog and MMSE scores), and neuro-inflammatory variables (i.e., circulating monocytes, cytokines). Results: Statistically significant correlations (p < 0.05 FWE) between right hippocampal shape and cognitive measurements and between left hippocampal shape and inflammatory indices were detected. The hippocampal field mostly involved was the lateral portion of bilateral hippocampi, mainly overlapping with Cornu Ammonis, extending along the entire longitudinal axis. Conclusions: A topological relationship between hippocampal atrophy and both cognitive profile and neuroinflammation is found; the association with neuroinflammatory indices is in line with the pattern of AD-Associated neuronal death, whereas the association with cognitive test might account for residual cognitive functions.",
keywords = "Alzheimer's disease, brain, flow cytometry, hippocampus, inflammation, Magnetic Resonance Imaging (MRI)",
author = "Monia Cabinio and Marina Saresella and Federica Piancone and Francesca LaRosa and Ivana Marventano and Guerini, {Franca Rosa} and Raffaello Nemni and Francesca Baglio and Mario Clerici",
year = "2018",
month = "1",
day = "1",
doi = "10.3233/JAD-180250",
language = "English",
volume = "66",
pages = "1131--1144",
journal = "Journal of Alzheimer's Disease",
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TY - JOUR

T1 - Association between Hippocampal Shape, Neuroinflammation, and Cognitive Decline in Alzheimer's Disease

AU - Cabinio, Monia

AU - Saresella, Marina

AU - Piancone, Federica

AU - LaRosa, Francesca

AU - Marventano, Ivana

AU - Guerini, Franca Rosa

AU - Nemni, Raffaello

AU - Baglio, Francesca

AU - Clerici, Mario

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Alzheimer's disease (AD) is a neurodegenerative condition characterized by memory impairment and general decrease in cognitive functions and daily living competences, that leads to a complete loss of autonomy. The pathogenesis of AD is characterized by the deposition of amyloid-β plaques (Aβ plaques) and neurofibrillary tangles, initially involving cortical and hippocampal structures, and neuroinflammation. To date, no studies have investigated the topological association between neuroinflammation and hippocampal shape in AD. Objective: The aim of the present study is to assess the association between hippocampal shape, cognitive profile, and neuroinflammation in a group of AD patients in the mild stage of the disease. Methods: Thirty-one patients with typical onset AD (mild stage) underwent MRI examination (1.5T scanner); hippocampal structures were segmented using a vertex-wise analysis (FSL-FIRST). Immune parameters were evaluated on peripheral blood mononuclear cells by flow-cytometry. Correlation analyses were performed between hippocampal shape and both cognitive profile (ADAS-Cog and MMSE scores), and neuro-inflammatory variables (i.e., circulating monocytes, cytokines). Results: Statistically significant correlations (p < 0.05 FWE) between right hippocampal shape and cognitive measurements and between left hippocampal shape and inflammatory indices were detected. The hippocampal field mostly involved was the lateral portion of bilateral hippocampi, mainly overlapping with Cornu Ammonis, extending along the entire longitudinal axis. Conclusions: A topological relationship between hippocampal atrophy and both cognitive profile and neuroinflammation is found; the association with neuroinflammatory indices is in line with the pattern of AD-Associated neuronal death, whereas the association with cognitive test might account for residual cognitive functions.

AB - Background: Alzheimer's disease (AD) is a neurodegenerative condition characterized by memory impairment and general decrease in cognitive functions and daily living competences, that leads to a complete loss of autonomy. The pathogenesis of AD is characterized by the deposition of amyloid-β plaques (Aβ plaques) and neurofibrillary tangles, initially involving cortical and hippocampal structures, and neuroinflammation. To date, no studies have investigated the topological association between neuroinflammation and hippocampal shape in AD. Objective: The aim of the present study is to assess the association between hippocampal shape, cognitive profile, and neuroinflammation in a group of AD patients in the mild stage of the disease. Methods: Thirty-one patients with typical onset AD (mild stage) underwent MRI examination (1.5T scanner); hippocampal structures were segmented using a vertex-wise analysis (FSL-FIRST). Immune parameters were evaluated on peripheral blood mononuclear cells by flow-cytometry. Correlation analyses were performed between hippocampal shape and both cognitive profile (ADAS-Cog and MMSE scores), and neuro-inflammatory variables (i.e., circulating monocytes, cytokines). Results: Statistically significant correlations (p < 0.05 FWE) between right hippocampal shape and cognitive measurements and between left hippocampal shape and inflammatory indices were detected. The hippocampal field mostly involved was the lateral portion of bilateral hippocampi, mainly overlapping with Cornu Ammonis, extending along the entire longitudinal axis. Conclusions: A topological relationship between hippocampal atrophy and both cognitive profile and neuroinflammation is found; the association with neuroinflammatory indices is in line with the pattern of AD-Associated neuronal death, whereas the association with cognitive test might account for residual cognitive functions.

KW - Alzheimer's disease

KW - brain

KW - flow cytometry

KW - hippocampus

KW - inflammation

KW - Magnetic Resonance Imaging (MRI)

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U2 - 10.3233/JAD-180250

DO - 10.3233/JAD-180250

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C2 - 30400090

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VL - 66

SP - 1131

EP - 1144

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

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