Association between HLA class I and class II alleles and HCV, HBV infection in patients with hepatocellular carcinoma

C. Lombardo, A. Mazzocchi, A. Tagger, M. L. Ribero, D. Settesoldi, J. Coppa, F. Arienti, P. Notti, V. Mazzaferro, F. Ravagnani

Research output: Contribution to journalArticlepeer-review


The mechanisms of susceptibility to chronic persistent hepatitis and development of hepatocellular carcinoma in HCV and HBV infected subjects are not well clarified but there are some evidence that immunogenetic factors may have a role. In the present study, we have evaluated the distribution of HLA class I and class II alleles in 65 hepatocarcinoma patients (24 subjects with HBV infection and 41 subjects with HCV infection) consecutively analyzed in the period 1996 through 2000, compared to 210 healthy blood donors as controls. HLA typing for the HLA-A and HLA-B loci was performed by serological techniques whereas HLA-C and HLA-class II high resolution typing were carried out by SSO-PCR and SSP-PCR methods. The frequency of DRB1*0701 was higher (p=0.053) in hepatocarcinoma patients than in control group. No significant difference in the frequencies of HLA-A and -B antigens was observed between patients and control group. The frequencies of DRB1*0301 and DRB1*1104 were higher in HBV infected tumor patients than in control group (p=0.026, RR=0.17; p=0.0084, RR=2.71, respectively). No significant differences were found for any of HLA antigens examined between hepatocarcinoma patients infected by HCV and the control group. In literature has been reported the association between HLA DQB1*0301 allele and spontaneous clearance of HCV. Since the same frequency of DQB1*0301 in HCV infected patients and control group has been found, our study does not seem to confirm the role of DQB1*0301 allele in self limiting HCV infection.

Original languageEnglish
Pages (from-to)309
Number of pages1
JournalEuropean Journal of Immunogenetics
Issue number2
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Immunology
  • Genetics


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