Helicobacter pylori is a Gram-negative bacterium involved in many gastro-duodenal pathologies and strictly associated with duodenal ulcer and gastric cancer. However, only a minority of Helicobacter pylori positive subjects develops gastric cancer suggesting that immunogenetic factors may play a role in the course of the disease. Since HLA is known to be involved in the susceptibility or resistance to diseases, we have evaluated the correlation between HLA class II alleles and the susceptibility to, or the course of, Helicobacter pylori infection. We have examinated HLA class II DRB1, DQB1 and DQA1 loci in 50 Helicobacter pylori negative, 56 Helicobacter pylori positive blood donors with gastric metaplasia and in 46 gastric cancer patients. Helicobacter pylori negative healthy donors were paired to sex and age with gastric metaplasia subjects. High resolution DNA typing was carried out by SSO-PCR and by SSP-PCR methods. A significative increase in the frequencies of DQA1*03 and DQB1*03 alleles has been observed in subjects with metaplasia and gastric cancer in comparison to Helicobacter pylori negative healthy blood donors (RR=5.19; RR=2.98, respectively). Our data suggest that HLA DQA1*03 and DQB1*03 alleles may be important in determining the susceptibility to, or the course of, Helicobacter pylori infection.
|Number of pages||1|
|Journal||European Journal of Immunogenetics|
|Publication status||Published - 2001|
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