Abstract
Objective: The association of known prognostic factors with immune cell counts and β2-microglobulin and soluble IL-2 receptor (sIL-2r) serum levels as markers of activation of the immune system was investigated in breast cancer. Methods: Two hundred thirty five operated stage I and II breast cancer patients to receive adjuvant treatment in IBSCG trials were assessed in a cross-sectional study immediately before the first treatment. Leukocytes, lymphocytes and lymphocyte subset counts, β2-microglobulin and sIL-2r serum levels were assessed as immunological parameters. Prognostic factors were tumor load, receptor status, patient characteristics, and contextual factors of the immune assessment (such as time of the day, time since surgery, type of surgery, concomitant medication, co-morbidity). Results: In an operated early stage breast cancer patient population, tumor load was not associated with immune cell counts, βn2-microglobulin, or sIL-2r before adjuvant treatment. There was a pattern of association of prognostically favorable factors such as estrogen receptor (ER) positive tumor and older age with higher NK cell counts or with β2-microglobulin or sIL-2r. In addition, immune cell counts and the markers of activation of the immune system were affected by several contextual factors, such as diurnal variability, time since surgery, type of surgery, and the intake of concomitant medication. Conclusions: The association of NK cell counts and β2-microglobulin or sIL-2r serum levels with prognostically favorable factors such as ER positive tumor and older age supports the assumption that the immune system plays a role in the course of early breast cancer. The exact nature of this role requires further study.
| Original language | English |
|---|---|
| Pages (from-to) | 279-287 |
| Number of pages | 9 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- β2-microglobulin
- Breast cancer
- Cellular immunity
- Prognosis
- SIL-2r
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Association between immunity and prognostic factors in early stage breast cancer patients before adjuvant treatment. / Sabbioni, Marzio E E; Siegrist, Hans Peter; Bacchi, Marisa; Bernhard, Jürg; Castiglione, Monica; Thürlimann, Beat; Bonnefoi, Hervé; Perey, Lucien; Herrmann, Richard; Goldhirsch, Aron; Hürny, Christoph.
In: Breast Cancer Research and Treatment, Vol. 59, No. 3, 2000, p. 279-287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between immunity and prognostic factors in early stage breast cancer patients before adjuvant treatment
AU - Sabbioni, Marzio E E
AU - Siegrist, Hans Peter
AU - Bacchi, Marisa
AU - Bernhard, Jürg
AU - Castiglione, Monica
AU - Thürlimann, Beat
AU - Bonnefoi, Hervé
AU - Perey, Lucien
AU - Herrmann, Richard
AU - Goldhirsch, Aron
AU - Hürny, Christoph
PY - 2000
Y1 - 2000
N2 - Objective: The association of known prognostic factors with immune cell counts and β2-microglobulin and soluble IL-2 receptor (sIL-2r) serum levels as markers of activation of the immune system was investigated in breast cancer. Methods: Two hundred thirty five operated stage I and II breast cancer patients to receive adjuvant treatment in IBSCG trials were assessed in a cross-sectional study immediately before the first treatment. Leukocytes, lymphocytes and lymphocyte subset counts, β2-microglobulin and sIL-2r serum levels were assessed as immunological parameters. Prognostic factors were tumor load, receptor status, patient characteristics, and contextual factors of the immune assessment (such as time of the day, time since surgery, type of surgery, concomitant medication, co-morbidity). Results: In an operated early stage breast cancer patient population, tumor load was not associated with immune cell counts, βn2-microglobulin, or sIL-2r before adjuvant treatment. There was a pattern of association of prognostically favorable factors such as estrogen receptor (ER) positive tumor and older age with higher NK cell counts or with β2-microglobulin or sIL-2r. In addition, immune cell counts and the markers of activation of the immune system were affected by several contextual factors, such as diurnal variability, time since surgery, type of surgery, and the intake of concomitant medication. Conclusions: The association of NK cell counts and β2-microglobulin or sIL-2r serum levels with prognostically favorable factors such as ER positive tumor and older age supports the assumption that the immune system plays a role in the course of early breast cancer. The exact nature of this role requires further study.
AB - Objective: The association of known prognostic factors with immune cell counts and β2-microglobulin and soluble IL-2 receptor (sIL-2r) serum levels as markers of activation of the immune system was investigated in breast cancer. Methods: Two hundred thirty five operated stage I and II breast cancer patients to receive adjuvant treatment in IBSCG trials were assessed in a cross-sectional study immediately before the first treatment. Leukocytes, lymphocytes and lymphocyte subset counts, β2-microglobulin and sIL-2r serum levels were assessed as immunological parameters. Prognostic factors were tumor load, receptor status, patient characteristics, and contextual factors of the immune assessment (such as time of the day, time since surgery, type of surgery, concomitant medication, co-morbidity). Results: In an operated early stage breast cancer patient population, tumor load was not associated with immune cell counts, βn2-microglobulin, or sIL-2r before adjuvant treatment. There was a pattern of association of prognostically favorable factors such as estrogen receptor (ER) positive tumor and older age with higher NK cell counts or with β2-microglobulin or sIL-2r. In addition, immune cell counts and the markers of activation of the immune system were affected by several contextual factors, such as diurnal variability, time since surgery, type of surgery, and the intake of concomitant medication. Conclusions: The association of NK cell counts and β2-microglobulin or sIL-2r serum levels with prognostically favorable factors such as ER positive tumor and older age supports the assumption that the immune system plays a role in the course of early breast cancer. The exact nature of this role requires further study.
KW - β2-microglobulin
KW - Breast cancer
KW - Cellular immunity
KW - Prognosis
KW - SIL-2r
UR - http://www.scopus.com/inward/record.url?scp=0034093818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034093818&partnerID=8YFLogxK
U2 - 10.1023/A:1006379925343
DO - 10.1023/A:1006379925343
M3 - Article
C2 - 10832598
AN - SCOPUS:0034093818
VL - 59
SP - 279
EP - 287
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 3
ER -