TY - JOUR
T1 - Association between left ventricular regional sympathetic denervation and mechanical dyssynchrony in phase analysis
T2 - A cardiac CZT study
AU - Gimelli, Alessia
AU - Liga, Riccardo
AU - Genovesi, Dario
AU - Giorgetti, Assuero
AU - Kusch, Annette
AU - Marzullo, Paolo
PY - 2014
Y1 - 2014
N2 - Purpose: To evaluate the relationships among myocardial sympathetic innervation, perfusion and mechanical synchronicity assessed with cardiac cadmium-zinc-telluride (CZT) scintigraphy. Methods: A group of 29 patients underwent an evaluation of myocardial perfusion with 99mTc- tetrofosmin CZT scintigraphy and adrenergic innervation with 123I-metaiodobenzylguanidine (MIBG) CZT scintigraphy. The summed rest score (SRS), motion score (SMS) and thickening score (STS), as well as the summed 123I-MIBG defect score (SS-MIBG), were determined. Regional tracer uptake for both 99mTc-tetrofosmin and 123I-MIBG was also calculated. Finally, the presence of significant myocardial mechanical dyssynchrony was evaluated in phase analysis on gated CZT images and the region of latest mechanical activation identified. Results: Significant mechanical dyssynchrony was present in 17 patients (59 %) and associated with higher SRS (P=0.030), SMS (P123I-MIBG uptake (P=0.012) that overwhelmed the effect of depressed regional perfusion. Conclusion: Left ventricular mechanical dyssynchrony is associated with greater depression in contractile function and greater impairments in regional myocardial perfusion and sympathetic activity. In patients with dyssynchrony, the region of latest mechanical activation is characterized by a significantly altered adrenergic tone.
AB - Purpose: To evaluate the relationships among myocardial sympathetic innervation, perfusion and mechanical synchronicity assessed with cardiac cadmium-zinc-telluride (CZT) scintigraphy. Methods: A group of 29 patients underwent an evaluation of myocardial perfusion with 99mTc- tetrofosmin CZT scintigraphy and adrenergic innervation with 123I-metaiodobenzylguanidine (MIBG) CZT scintigraphy. The summed rest score (SRS), motion score (SMS) and thickening score (STS), as well as the summed 123I-MIBG defect score (SS-MIBG), were determined. Regional tracer uptake for both 99mTc-tetrofosmin and 123I-MIBG was also calculated. Finally, the presence of significant myocardial mechanical dyssynchrony was evaluated in phase analysis on gated CZT images and the region of latest mechanical activation identified. Results: Significant mechanical dyssynchrony was present in 17 patients (59 %) and associated with higher SRS (P=0.030), SMS (P123I-MIBG uptake (P=0.012) that overwhelmed the effect of depressed regional perfusion. Conclusion: Left ventricular mechanical dyssynchrony is associated with greater depression in contractile function and greater impairments in regional myocardial perfusion and sympathetic activity. In patients with dyssynchrony, the region of latest mechanical activation is characterized by a significantly altered adrenergic tone.
KW - CZT
KW - Mechanical dyssynchrony
KW - Phase analysis
UR - http://www.scopus.com/inward/record.url?scp=84898814380&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898814380&partnerID=8YFLogxK
U2 - 10.1007/s00259-013-2640-3
DO - 10.1007/s00259-013-2640-3
M3 - Article
C2 - 24310439
AN - SCOPUS:84898814380
VL - 41
SP - 946
EP - 955
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 5
ER -