Association between low-activity allele of cathecolamine-o-methyl- transferase (COMT) and borderline personality disorder in an italian population

Matteo Lazzaretti, Dora Fabbro, Michela Sala, Kether Del Toso, Giulia De Vidovich, Elisa Marraffini, Niccolò Morandotti, Francesca Gambini, Francesco Barale, Matteo Balestrieri, Giuseppe Damante, Edgardo Caverzasi, Paolo Brambilla

Research output: Contribution to journalArticle

Abstract

The objective of the present study was to test the association between Borderline Personality Disorder (BPD) and the cathecolamine-O-methyl-transferase (COMT) low-activity (Met158) single nucleotide polymorphism (SNP). In this case-control study, DNA was obtained from venous blood of 19 BPD patients and 36 healthy subjects. COMT-Val158Met single-nucleotide polymorphism was genotyped by predesigned SNP assay. The COMT Met158 allele was over-represented in patients with BPD in comparison to normal subjects (68.4% vs 44.4%, respectively; Fisher exact test, p =.02). In terms of genotype, the Met158Met subjects were more frequent in patients versus controls (47.4% vs 22.2%, respectively), whereas the high-activity genotype Val158Val was under-represented (10.5% vs 33.3%, respectively). The allele encoding for the COMT with low enzymatic efficiency was found to be over-represented in BPD, possibly resulting in excessive synaptic dopaminergic activity and ultimately affecting externalizing behaviours, such as impulsivity and aggressiveness.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalBehavioral Medicine
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 1 2013

Keywords

  • Aggressiveness
  • Dopamine
  • Externalizing behaviors
  • Impulsivity
  • Memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology

Fingerprint Dive into the research topics of 'Association between low-activity allele of cathecolamine-o-methyl- transferase (COMT) and borderline personality disorder in an italian population'. Together they form a unique fingerprint.

  • Cite this

    Lazzaretti, M., Fabbro, D., Sala, M., Del Toso, K., De Vidovich, G., Marraffini, E., Morandotti, N., Gambini, F., Barale, F., Balestrieri, M., Damante, G., Caverzasi, E., & Brambilla, P. (2013). Association between low-activity allele of cathecolamine-o-methyl- transferase (COMT) and borderline personality disorder in an italian population. Behavioral Medicine, 39(2), 25-28. https://doi.org/10.1080/08964289.2012.722134