TY - JOUR
T1 - Association between male infertility and male-specific malignancies
T2 - systematic review and meta-analysis of population-based retrospective cohort studies
AU - Del Giudice, Francesco
AU - Kasman, Alex M.
AU - De Berardinis, Ettore
AU - Busetto, Gian Maria
AU - Belladelli, Federico
AU - Eisenberg, Michael L.
N1 - Publisher Copyright:
© 2020 American Society for Reproductive Medicine
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - Objective: To investigate the current evidence that correlates impaired male fertility with the risk of developing male-related malignancies. Design: Systematic review and meta-analysis of population-based retrospective cohort studies. Setting: Not applicable. Patient(s): Men diagnosed with impaired fertility status and subsequently observed to determine incidence risk in developing testicular cancer (TCa) or prostate cancer (PCa). Intervention(s): Not applicable. Main Outcome Measure(s): Pooled risk ratio (RR) differences among male factor infertility subjects compared with a fertile control population, and meta-regression analysis according to age at baseline, mean follow-up, range of study time, and year of publication. Result(s): Six studies met the inclusion criteria and were critically examined. Four studies examined male infertility and TCa (n = 161,634; 174 TCa cases), and four examined infertility in relation to PCa (n = 183,950 men; 377 PCa cases) from 1963 to 2014. The pooled RR was 2.033 (95% confidence interval [CI], 1.66–2.48); heterogeneity: Q = 3.04 (degree of freedom [df] = 3); I2 = 1.55% for TCa and 1.68 (95% CI, 1.17–2.4); Q = 23.3(df = 3); I2 = 87.1% for PCa. Conclusion(s): Male infertility was associated with a subsequent risk of both TCa and PCa. Although the clinical significance of these findings remains uncertain, future studies should evaluate the underlying mechanisms to determine whether testis and prostate screening practices should be altered in men with male infertility. Clinical Trial Registration Number: PROSPERO 167277
AB - Objective: To investigate the current evidence that correlates impaired male fertility with the risk of developing male-related malignancies. Design: Systematic review and meta-analysis of population-based retrospective cohort studies. Setting: Not applicable. Patient(s): Men diagnosed with impaired fertility status and subsequently observed to determine incidence risk in developing testicular cancer (TCa) or prostate cancer (PCa). Intervention(s): Not applicable. Main Outcome Measure(s): Pooled risk ratio (RR) differences among male factor infertility subjects compared with a fertile control population, and meta-regression analysis according to age at baseline, mean follow-up, range of study time, and year of publication. Result(s): Six studies met the inclusion criteria and were critically examined. Four studies examined male infertility and TCa (n = 161,634; 174 TCa cases), and four examined infertility in relation to PCa (n = 183,950 men; 377 PCa cases) from 1963 to 2014. The pooled RR was 2.033 (95% confidence interval [CI], 1.66–2.48); heterogeneity: Q = 3.04 (degree of freedom [df] = 3); I2 = 1.55% for TCa and 1.68 (95% CI, 1.17–2.4); Q = 23.3(df = 3); I2 = 87.1% for PCa. Conclusion(s): Male infertility was associated with a subsequent risk of both TCa and PCa. Although the clinical significance of these findings remains uncertain, future studies should evaluate the underlying mechanisms to determine whether testis and prostate screening practices should be altered in men with male infertility. Clinical Trial Registration Number: PROSPERO 167277
KW - Epidemiology
KW - male factor infertility
KW - prostate cancer
KW - relative risk
KW - testicular cancer
UR - http://www.scopus.com/inward/record.url?scp=85088218027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088218027&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2020.04.042
DO - 10.1016/j.fertnstert.2020.04.042
M3 - Article
C2 - 32709378
AN - SCOPUS:85088218027
VL - 114
SP - 984
EP - 996
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 5
ER -