In this study, we explored if urinary lithogenic risk parameters could have some application for monitoring bone health status. We recruited 20 women with postmenopausal osteopenia and a negative medical history for nephrolithiasis. Markers of lithogenic risk were evaluated on 24-h urine and fastingmorning urine. Serum levels of bone turnover markers (BTM) were measured in fasting-blood samples. We found that cross-linked telopeptide of type I collagen (CTX) was significantly correlated with 24-h calcium excretion. N-terminal propeptide of type I procollagen (PINP) correlated with 24-h excretion of potassium, calcium and citrate. CTX had considerably increased in patients with pH less than 5.5. Low citrate levels (less than 3.3 mmol/24 h) were associated with lower levels of CTX and PINP. Our findings suggest that a low-grade acidosis and some lithogenic risk factors are detectable in a proportion of patients with postmenopausal osteopenia. Further studies are necessary to confirm that this evaluation could be clinically relevant.
|Number of pages||11|
|Journal||Journal of Biological Regulators and Homeostatic Agents|
|Issue number||suppl. 1|
|Publication status||Published - 2016|
Granchi, D., Caudarella, R., Claudio, R., Spinnato, P., Bazzocchi, A., Torreggiani, E., Massa, A., & Baldini, N. (2016). Association between markers of bone loss and urinary lithogenic risk factors in osteopenic postmenopausal women. Journal of Biological Regulators and Homeostatic Agents, 4(suppl. 1), 141-151.