Association between markers of emphysema and more severe chronic obstructive pulmonary disease

P. Boschetto, S. Quintavalle, E. Zeni, S. Leprotti, A. Potena, L. Ballerin, A. Papi, G. Palladini, M. Luisetti, L. Annovazzi, P. Iadarola, E. De Rosa, L. M. Fabbri, C. E. Mapp

Research output: Contribution to journalArticle

Abstract

Background: The predominant emphysema phenotype is associated with more severe airflow limitation in patients with chronic obstructive pulmonary disease (COPD). A study was undertaken to investigate whether COPD patients, with or without emphysema quantitatively confirmed by high resolution computed tomography (HRCT), have different COPD severity as assessed by the BODE index (body mass index, airflow obstruction, dyspnoea, exercise performance) and inspiratory capacity to total lung capacity ratio (IC/TLC), and by different biological markers of lung parenchymal destruction. Methods: Twenty six outpatients with COPD and eight healthy non-smokers were examined. Each subject underwent HRCT scanning, pulmonary function tests, cell counts, and measurements of neutrophil elastase, matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in induced sputum, as well as measurement of desmosine, a marker of elastin degradation in urine, plasma and sputum. Results: Patients with HRCT confirmed emphysema had a higher BODE index and lower IC/TLC ratio than subjects without HRCT confirmed emphysema and controls. Forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity ratio, and carbon monoxide transfer coefficient were lower, whereas the number of eosinophils, MMP-9, and the MMP-9/TIMP-1 ratio in sputum were higher in patients with emphysema. In COPD patients the number of sputum eosinophils was the biological variable that correlated positively with the HRCT score of emphysema (p = 0.04). Conclusions: These results suggest that COPD associated with HRCT confirmed emphysema is characterised by more severe lung function impairment, more intense airway inflammation and, possibly, more serious systemic dysfunction than COPD not associated with HRCT confirmed emphysema.

Original languageEnglish
Pages (from-to)1037-1042
Number of pages6
JournalThorax
Volume61
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Emphysema
Chronic Obstructive Pulmonary Disease
Tomography
Sputum
Matrix Metalloproteinase 9
Inspiratory Capacity
Total Lung Capacity
Tissue Inhibitor of Metalloproteinase-1
Forced Expiratory Volume
Eosinophils
Desmosine
Lung
Leukocyte Elastase
Matrix Metalloproteinase Inhibitors
Elastin
Respiratory Function Tests
Vital Capacity
Carbon Monoxide
Dyspnea
Body Mass Index

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Boschetto, P., Quintavalle, S., Zeni, E., Leprotti, S., Potena, A., Ballerin, L., ... Mapp, C. E. (2006). Association between markers of emphysema and more severe chronic obstructive pulmonary disease. Thorax, 61(12), 1037-1042. https://doi.org/10.1136/thx.2006.058321

Association between markers of emphysema and more severe chronic obstructive pulmonary disease. / Boschetto, P.; Quintavalle, S.; Zeni, E.; Leprotti, S.; Potena, A.; Ballerin, L.; Papi, A.; Palladini, G.; Luisetti, M.; Annovazzi, L.; Iadarola, P.; De Rosa, E.; Fabbri, L. M.; Mapp, C. E.

In: Thorax, Vol. 61, No. 12, 12.2006, p. 1037-1042.

Research output: Contribution to journalArticle

Boschetto, P, Quintavalle, S, Zeni, E, Leprotti, S, Potena, A, Ballerin, L, Papi, A, Palladini, G, Luisetti, M, Annovazzi, L, Iadarola, P, De Rosa, E, Fabbri, LM & Mapp, CE 2006, 'Association between markers of emphysema and more severe chronic obstructive pulmonary disease', Thorax, vol. 61, no. 12, pp. 1037-1042. https://doi.org/10.1136/thx.2006.058321
Boschetto P, Quintavalle S, Zeni E, Leprotti S, Potena A, Ballerin L et al. Association between markers of emphysema and more severe chronic obstructive pulmonary disease. Thorax. 2006 Dec;61(12):1037-1042. https://doi.org/10.1136/thx.2006.058321
Boschetto, P. ; Quintavalle, S. ; Zeni, E. ; Leprotti, S. ; Potena, A. ; Ballerin, L. ; Papi, A. ; Palladini, G. ; Luisetti, M. ; Annovazzi, L. ; Iadarola, P. ; De Rosa, E. ; Fabbri, L. M. ; Mapp, C. E. / Association between markers of emphysema and more severe chronic obstructive pulmonary disease. In: Thorax. 2006 ; Vol. 61, No. 12. pp. 1037-1042.
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T1 - Association between markers of emphysema and more severe chronic obstructive pulmonary disease

AU - Boschetto, P.

AU - Quintavalle, S.

AU - Zeni, E.

AU - Leprotti, S.

AU - Potena, A.

AU - Ballerin, L.

AU - Papi, A.

AU - Palladini, G.

AU - Luisetti, M.

AU - Annovazzi, L.

AU - Iadarola, P.

AU - De Rosa, E.

AU - Fabbri, L. M.

AU - Mapp, C. E.

PY - 2006/12

Y1 - 2006/12

N2 - Background: The predominant emphysema phenotype is associated with more severe airflow limitation in patients with chronic obstructive pulmonary disease (COPD). A study was undertaken to investigate whether COPD patients, with or without emphysema quantitatively confirmed by high resolution computed tomography (HRCT), have different COPD severity as assessed by the BODE index (body mass index, airflow obstruction, dyspnoea, exercise performance) and inspiratory capacity to total lung capacity ratio (IC/TLC), and by different biological markers of lung parenchymal destruction. Methods: Twenty six outpatients with COPD and eight healthy non-smokers were examined. Each subject underwent HRCT scanning, pulmonary function tests, cell counts, and measurements of neutrophil elastase, matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in induced sputum, as well as measurement of desmosine, a marker of elastin degradation in urine, plasma and sputum. Results: Patients with HRCT confirmed emphysema had a higher BODE index and lower IC/TLC ratio than subjects without HRCT confirmed emphysema and controls. Forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity ratio, and carbon monoxide transfer coefficient were lower, whereas the number of eosinophils, MMP-9, and the MMP-9/TIMP-1 ratio in sputum were higher in patients with emphysema. In COPD patients the number of sputum eosinophils was the biological variable that correlated positively with the HRCT score of emphysema (p = 0.04). Conclusions: These results suggest that COPD associated with HRCT confirmed emphysema is characterised by more severe lung function impairment, more intense airway inflammation and, possibly, more serious systemic dysfunction than COPD not associated with HRCT confirmed emphysema.

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