Association between maternal omega-3 polyunsaturated fatty acids supplementation and preterm delivery: A proteomic study

Maurizio Bruschi, Laura Santucci, Andrea Petretto, Martina Bartolocci, Marco Marchisio, Gian Marco Ghiggeri, Enrico Verrina, Luca A Ramenghi, Isabella Panfoli, Giovanni Candiano

Research output: Contribution to journalArticlepeer-review


Maternal nutrition during pregnancy influences offspring health. Dietary supplementation of pregnant women with (n-3) long-chain polyunsaturated fatty acids (PUFA) was shown to exert beneficial effects on offspring, through yet unknown mechanisms. Here, we conducted a dietary intervention study on a cohort of 10 women diagnosed with threatened preterm labor with a nutritional integration with eicosapentaenoic and docosahexaenoic acids. Microvesicles (MV) isolated form arterial cord blood of the treated cohort offspring and also of a randomized selection of 10 untreated preterm and 12 term newborns, were characterized by dynamic light scattering and analyzed by proteomic and statistical analysis. Glutathione synthetase was the protein bearing the highest discrimination ability between cohorts. ELISA assay showed that glutathione synthetase was more abundant in cord blood from untreated preterm compared to the other conditions. Assay of free SH-groups showed that serum of preterm subjects was oxidized. Data suggest that preterm suffer from oxidative stress, which was lower in the treated cohort. This study confirms that MV are a representative sample of the individual status and the efficacy of dietary intervention with PUFA in human pregnancy in terms of lowered inflammatory status, increased gestational age and weight at birth.

Original languageEnglish
Pages (from-to)6322-6334
Number of pages13
JournalFASEB journal : official publication of the Federation of American Societies for Experimental Biology
Issue number5
Publication statusPublished - May 2020


  • Adult
  • Dietary Supplements
  • Fatty Acids, Omega-3/administration & dosage
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Maternal Nutritional Physiological Phenomena
  • Obstetric Labor, Premature/metabolism
  • Pregnancy
  • Premature Birth/diet therapy
  • Proteome/analysis
  • Young Adult

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