Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

Vilma Guimaraes, Rafael Guimaraes, Lucas Brandao, Maria Fernanda Piffer Tomasi Baldez da Silva, Michele Milanese, Ludovica Segat, Henrique Castelletti, Danielly Bruneska, Josè Luiz de Lima Filho, Antonio Carlos de Freitas, Luiz Claudio Arraes, Cintia Rocha, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

We studied the association between high-risk human papillomavirus (HPV) infection and MBL2 functional polymorphisms in a group of 180 high-risk HPV-infected women and 180 healthy control subjects. The most frequent high-risk HPV genotypes were 16 (47.2%), 31 (11.7%), 33 (5%), and 18 (2.2%), respectively. Of the 180 HPV-infected women, 99 presented with uterine cervical cancer and 81 did not. No differences in MBL2 genotype or in allelic or haplotype frequencies were found between HPV patients who developed cervical uterine cancer and those who did not. When considering combined genotypes grouped according to MBL production (designated as high, low, and deficient producers), we detected a significant difference between healthy controls and high-risk HPV-positive patients, the latter group showing increased frequencies of deficient-producer genotypes (14.4% vs 9.4% in the healthy control group, corrected p = 0.04). In conclusion, a correlation between MBL2 polymorphisms and high-risk HPV infection was found in this study.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalHuman Immunology
Volume69
Issue number4-5
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Brazilian women
  • Cervical uterine cancer
  • Genetic polymorphisms
  • High- and low-risk HPV genotypes
  • Innate immunity
  • MBL2

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Guimaraes, V., Guimaraes, R., Brandao, L., Baldez da Silva, M. F. P. T., Milanese, M., Segat, L., Castelletti, H., Bruneska, D., de Lima Filho, J. L., de Freitas, A. C., Arraes, L. C., Rocha, C., & Crovella, S. (2008). Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women. Human Immunology, 69(4-5), 273-278. https://doi.org/10.1016/j.humimm.2008.03.002