Association between migraine and ACE gene (insertion/deletion) polymorphism: The BioBIM study

Raffaele Palmirotta, Piero Barbanti, Giorgia Ludovici, Maria Laura De Marchis, Cristiano Ialongo, Gabriella Egeo, Cinzia Aurilia, Luisa Fofi, Pasquale Abete, Antonella Spila, Patrizia Ferroni, David Della-Morte, Fiorella Guadagni

Research output: Contribution to journalArticlepeer-review


Aim: In the present case-control study, we investigated the correlation between the common ACE insertion/deletion (I/D) polymorphism and migraine. Materials & methods: Genotyping of the ACE I/D variant was performed in 502 Caucasian patients with migraine and 323 age-, sex- and race/ethnicity-matched healthy controls. We investigated associations between ACE genetic variants and sociodemographic and/or clinical features of migraineurs. Results: We found a significant association between ACE insertion/insertion (I/I) polymorphism and lower use of pharmacological prophylaxis in migraine patients with aura and in those with chronic migraine. Moreover, ACE I/I polymorphism was significantly more common in migraine patients with aura who had a negative family history of migraine. Conclusion: Our data suggest that although the ACE I/D polymorphism is not a direct risk factor for migraine, the ACE I/I genotype may influence the clinical feature of this disease being associated with reduced use of prophylactic agents in patients with migraine with aura and in those with chronic migraine. Original submitted 5 June 2013; Revision submitted 16 September 201.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
Issue number2
Publication statusPublished - Feb 2014


  • ACE I/D polymorphism
  • genetics
  • migraine
  • pharmacological prophylaxis

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine
  • Medicine(all)


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