Association between nutrient-based dietary patterns and bladder cancer in Italy

Valeria Edefonti, Carlo La Vecchia, Matteo Di Maso, Anna Crispo, Jerry Polesel, Massimo Libra, Maria Parpinel, Diego Serraino, Monica Ferraroni, Francesca Bravi

Research output: Contribution to journalArticlepeer-review


Limited knowledge is available on dietary patterns and bladder cancer risk. We analyzed data from an Italian case-control study carried out between 2003 and 2014, including 690 incident bladder cancer cases and 665 hospital-controls. We derived nutrient-based dietary patterns applying principal component factor analysis on 28 selected nutrients. We categorized factor scores according to quartiles, and estimated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) through logistic regression models, adjusted for major confounding factors. We identified four dietary patterns named “Animal products”, “Vitamins and fiber”, “Starch-rich”, and “Animal unsaturated fatty acids”. We found an inverse association between the “Vitamins and fiber” pattern and bladder cancer (OR = 0.70, 95% CI: 0.48–0.99, IV versus I quartile category). Inverse relationships of borderline significance were also found for the “Animal products” and the “Animal unsaturated fatty acids” dietary patterns. No significant association was evident for the “Starch-rich” pattern. The current study allowed us to identify major dietary patterns in this Italian population. Our study confirms available evidence and shows that scoring high on a fruit-and-vegetables pattern provides beneficial effects on bladder cancer risk.

Original languageEnglish
Article number1584
Issue number6
Publication statusPublished - Jun 2020


  • Bladder cancer
  • Case-control study
  • Diet
  • Dietary patterns
  • Factor analysis

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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