Association between obesity and circulating brain-derived neurotrophic factor (BDNF) levels: Systematic review of literature and meta-analysis

Leonardo Sandrini, Alessandro Di Minno, Patrizia Amadio, Alessandro Ieraci, Elena Tremoli, Silvia S. Barbieri

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Reduction in brain-derived neurotrophic factor (BDNF) expression in the brain as well as mutations in BDNF gene and/or of its receptor are associated to obesity in both human and animal models. However, the association between circulating levels of BDNF and obesity is still not defined. To answer this question, we performed a meta-analysis carrying out a systematic search in electronic databases. Ten studies (307 obese patients and 236 controls) were included in the analysis. Our data show that obese patients have levels of BDNF similar to those of controls (SMD: 0.01, 95% CI: −0.28, 0.30, p = 0.94). The lack of difference was further confirmed both in studies in which BDNF levels were assessed in serum (MD: −0.93 ng/mL, 95% CI: −3.34, 1.48, p = 0.45) and in plasma (MD: 0.15 ng/mL, 95% CI: −0.09, 0.39, p = 0.23). Data evaluation has shown that some bias might affect BDNF measurements (e.g., subject recruitment, procedures of sampling, handling, and storage), leading to a difficult interpretation of the results. Standardization of the procedures is still needed to reach strong, affordable, and reliable conclusions.

Original languageEnglish
Article number2281
JournalInternational Journal of Molecular Sciences
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 3 2018

Fingerprint

obesity
Brain-Derived Neurotrophic Factor
brain
Meta-Analysis
Brain
Obesity
Surface mount technology
animal models
standardization
Standardization
mutations
Nerve Growth Factors
genes
Animals
serums
Animal Models
Genes
Association reactions
Databases
Sampling

Keywords

  • BDNF
  • Meta-analysis
  • Obesity

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Association between obesity and circulating brain-derived neurotrophic factor (BDNF) levels : Systematic review of literature and meta-analysis. / Sandrini, Leonardo; Di Minno, Alessandro; Amadio, Patrizia; Ieraci, Alessandro; Tremoli, Elena; Barbieri, Silvia S.

In: International Journal of Molecular Sciences, Vol. 19, No. 8, 2281, 03.08.2018.

Research output: Contribution to journalReview article

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