Association between obsessive compulsive disorder and the COMT gene

D. Di Bella, M. C. Cavallini, M. Henin, M. Catalano, L. Bellodi

Research output: Contribution to journalArticle

Abstract

Obsessive compulsive disorder (OCD) is a clinical condition characterized by persistent, unwanted thoughts and ritualistic behaviours. Data from families and segregation studies strongly support the hypothesis of a genetic liability. Catechol-O-methyltransferase (COMT) is a key modulator of catecholaminergic neurotransmission. Recently, a significant association between a common functional polymorphism (Met 158 Val) in the coding sequence of COMT, resulting in a three to fourfold reduction in enzyme activity, and susceptibility for OCD was found, particularly in males. We decided to investigate a sample of OCD patients, diagnosed according to DSM IV criteria, for a possible association with COMT alleles using a haplotype relative risk (HER) strategy. We collected 49 nuclear families of OCD probands (26 males, 23 females) of Italian descent. The distribution of both genotypes and alleles was not significantly different between male and female OCD patients (P = 0.365 for genotypes; P = 0.950 for alleles). Furthermore, allele frequencies in the OCD sample (high activity allele = 0.55; low activity allele = 0.45) are not different from those reported in the literature for Caucasians. HRR analysis produced negative results in the total sample (P = 0.4444) as well as subdivided the sample according to the sex of the proband (P = 0.8320 for males; P = 0.9765 for females). Our study failed to confirm the previous finding of an association between the COMT low activity allele and male OCD.

Original languageEnglish
Pages (from-to)516
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number6
Publication statusPublished - Nov 6 1998

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Catechol O-Methyltransferase
Obsessive-Compulsive Disorder
Alleles
Genes
Genotype
Nuclear Family
Gene Frequency
Synaptic Transmission
Diagnostic and Statistical Manual of Mental Disorders
Haplotypes
Enzymes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Di Bella, D., Cavallini, M. C., Henin, M., Catalano, M., & Bellodi, L. (1998). Association between obsessive compulsive disorder and the COMT gene. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 516.

Association between obsessive compulsive disorder and the COMT gene. / Di Bella, D.; Cavallini, M. C.; Henin, M.; Catalano, M.; Bellodi, L.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 81, No. 6, 06.11.1998, p. 516.

Research output: Contribution to journalArticle

Di Bella, D, Cavallini, MC, Henin, M, Catalano, M & Bellodi, L 1998, 'Association between obsessive compulsive disorder and the COMT gene', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 6, pp. 516.
Di Bella, D. ; Cavallini, M. C. ; Henin, M. ; Catalano, M. ; Bellodi, L. / Association between obsessive compulsive disorder and the COMT gene. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 ; Vol. 81, No. 6. pp. 516.
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