Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population

Irene Marta Predazzi, Giuseppe Danilo Norata, Lucia Vecchione, Katia Garlaschelli, Francesca Amati, Liliana Grigore, Lucia Cutuli, Angela Pirillo, Simona Tramontana, Francesco Romeo, Giuseppe Novelli, Alberico Luigi Catapano

Research output: Contribution to journalArticle

Abstract

Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study). Results: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers. Conclusions: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.

Original languageEnglish
Article numbere31086
JournalPLoS One
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 9 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population'. Together they form a unique fingerprint.

  • Cite this

    Predazzi, I. M., Norata, G. D., Vecchione, L., Garlaschelli, K., Amati, F., Grigore, L., Cutuli, L., Pirillo, A., Tramontana, S., Romeo, F., Novelli, G., & Catapano, A. L. (2012). Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population. PLoS One, 7(2), [e31086]. https://doi.org/10.1371/journal.pone.0031086