Association Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignancies

Giovanni Marchegiani, Giuseppe Malleo, Jan G. D'Haese, Patrick Wenzel, Muharrem Keskin, Luigi Pugliese, Alex Borin, Valentina Benning, Linda Nilsson, Nevin Oruc, Ralf Segersvard, Helmut Friess, Roland Schmid, Matthias Löhr, Patrick Maisonneuve, Claudio Bassi, Güralp O. Ceyhan, Roberto Salvia, Marco Del Chiaro

Research output: Contribution to journalArticle

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Abstract

Background & Aims: The association between pancreatic intraductal papillary mucinous neoplasms (IPMNs) and extrapancreatic neoplasms (EPNs) is controversial. We performed a multicenter observational study to assess the incidence of EPNs after an IPMN diagnosis. Methods: 1340 patients with IPMNs were evaluated from 2000 through 2013 at 4 academic institutions in Europe for development of EPN. To estimate the actual incidence of EPN, we excluded patients with an EPN previous or synchronous to the IPMN, and patients who had been followed for less than 12 months, resulting in a study population of 816 patients. The incidence of EPN was compared with sex-specific, age-adjusted European cancer statistics; the standardized incidence ratio (SIR), and the 5- and 10-year cumulative incidence rates were calculated. Results: A total of 290/1340 patients had a history of EPN (prevalence of 21.6%). In this subgroup of patients, the IPMN was discovered incidentally in 241. Among the 816 patients included in the incidence analysis, 50 developed an EPN after a median time of 46 months from study enrollment. The incidence of any EPN was not greater in patients with than without IPMN with a SIR of 1.48 (95% confidence interval, 0.94-2.22) in males and of 1.39 (95% CI 0.90-2.05) in females. The 5- and 10-year cumulative incidence rates for development of EPN in patients with IPMN were 7.9% and 16.6% in men, and 3.4% and 23.1% in women. Conclusions: Patients with IPMN do not have a significantly higher incidence of EPNs than the general European population. It might not be necessary to screen patients with IPMN for EPN.

Original languageEnglish
Pages (from-to)1162-1169
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Neoplasms
Incidence
Population
Multicenter Studies
Observational Studies
Confidence Intervals

Keywords

  • Cancer
  • Cystic Lesion of the Pancreas
  • Extrapancreatic Tumors
  • Follow Up

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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Association Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignancies. / Marchegiani, Giovanni; Malleo, Giuseppe; D'Haese, Jan G.; Wenzel, Patrick; Keskin, Muharrem; Pugliese, Luigi; Borin, Alex; Benning, Valentina; Nilsson, Linda; Oruc, Nevin; Segersvard, Ralf; Friess, Helmut; Schmid, Roland; Löhr, Matthias; Maisonneuve, Patrick; Bassi, Claudio; Ceyhan, Güralp O.; Salvia, Roberto; Del Chiaro, Marco.

In: Clinical Gastroenterology and Hepatology, Vol. 13, No. 6, 01.06.2015, p. 1162-1169.

Research output: Contribution to journalArticle

Marchegiani, G, Malleo, G, D'Haese, JG, Wenzel, P, Keskin, M, Pugliese, L, Borin, A, Benning, V, Nilsson, L, Oruc, N, Segersvard, R, Friess, H, Schmid, R, Löhr, M, Maisonneuve, P, Bassi, C, Ceyhan, GO, Salvia, R & Del Chiaro, M 2015, 'Association Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignancies', Clinical Gastroenterology and Hepatology, vol. 13, no. 6, pp. 1162-1169. https://doi.org/10.1016/j.cgh.2014.11.029
Marchegiani, Giovanni ; Malleo, Giuseppe ; D'Haese, Jan G. ; Wenzel, Patrick ; Keskin, Muharrem ; Pugliese, Luigi ; Borin, Alex ; Benning, Valentina ; Nilsson, Linda ; Oruc, Nevin ; Segersvard, Ralf ; Friess, Helmut ; Schmid, Roland ; Löhr, Matthias ; Maisonneuve, Patrick ; Bassi, Claudio ; Ceyhan, Güralp O. ; Salvia, Roberto ; Del Chiaro, Marco. / Association Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignancies. In: Clinical Gastroenterology and Hepatology. 2015 ; Vol. 13, No. 6. pp. 1162-1169.
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AU - Wenzel, Patrick

AU - Keskin, Muharrem

AU - Pugliese, Luigi

AU - Borin, Alex

AU - Benning, Valentina

AU - Nilsson, Linda

AU - Oruc, Nevin

AU - Segersvard, Ralf

AU - Friess, Helmut

AU - Schmid, Roland

AU - Löhr, Matthias

AU - Maisonneuve, Patrick

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