Association between perihematomal cerebral blood volume and intracerebral hemorrhage expansion: A computed tomography perfusion study

Andrea Morotti; Giorgio Busto; Andrea Bernardoni; Carmine Tamborino; Enrico Fainardi

doi:10.1002/ana.25466

Association between perihematomal cerebral blood volume and intracerebral hemorrhage expansion: A computed tomography perfusion study

Andrea Morotti, Giorgio Busto, Andrea Bernardoni, Carmine Tamborino, Enrico Fainardi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated whether computed tomography (CT) perfusion can identify intracerebral hemorrhage patients at high risk of hematoma growth (HG). A total of 155 subjects underwent CT perfusion on admission. Variables associated with log-transformed absolute HG were explored with multivariable linear regression. Perihematomal cerebral blood volume (CBV) was inversely associated with HG (B = -0.20; p < 0.001), independently from blood pressure, hematoma volume, and other confounders. This association was not dose dependent, and only very low CBV (<1.4 ml/100 g) was significantly associated with HG (B = 0.25; p < 0.001). In conclusion, reduced perihematomal CBV is associated with HG, suggesting a potential role of the perihematomal region in the pathophysiology of hematoma enlargement. ANN NEUROL 2019.

Original language	English
Pages (from-to)	943-7
Number of pages	5
Journal	Annals of Neurology
Volume	85
Issue number	6
DOIs	https://doi.org/10.1002/ana.25466
Publication status	Published - Jun 12 2019

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title = "Association between perihematomal cerebral blood volume and intracerebral hemorrhage expansion: A computed tomography perfusion study",

abstract = "We investigated whether computed tomography (CT) perfusion can identify intracerebral hemorrhage patients at high risk of hematoma growth (HG). A total of 155 subjects underwent CT perfusion on admission. Variables associated with log-transformed absolute HG were explored with multivariable linear regression. Perihematomal cerebral blood volume (CBV) was inversely associated with HG (B = -0.20; p < 0.001), independently from blood pressure, hematoma volume, and other confounders. This association was not dose dependent, and only very low CBV (<1.4 ml/100 g) was significantly associated with HG (B = 0.25; p < 0.001). In conclusion, reduced perihematomal CBV is associated with HG, suggesting a potential role of the perihematomal region in the pathophysiology of hematoma enlargement. ANN NEUROL 2019.",

author = "Andrea Morotti and Giorgio Busto and Andrea Bernardoni and Carmine Tamborino and Enrico Fainardi",

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T1 - Association between perihematomal cerebral blood volume and intracerebral hemorrhage expansion

T2 - A computed tomography perfusion study

AU - Morotti, Andrea

AU - Busto, Giorgio

AU - Bernardoni, Andrea

AU - Tamborino, Carmine

AU - Fainardi, Enrico

PY - 2019/6/12

Y1 - 2019/6/12

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AB - We investigated whether computed tomography (CT) perfusion can identify intracerebral hemorrhage patients at high risk of hematoma growth (HG). A total of 155 subjects underwent CT perfusion on admission. Variables associated with log-transformed absolute HG were explored with multivariable linear regression. Perihematomal cerebral blood volume (CBV) was inversely associated with HG (B = -0.20; p < 0.001), independently from blood pressure, hematoma volume, and other confounders. This association was not dose dependent, and only very low CBV (<1.4 ml/100 g) was significantly associated with HG (B = 0.25; p < 0.001). In conclusion, reduced perihematomal CBV is associated with HG, suggesting a potential role of the perihematomal region in the pathophysiology of hematoma enlargement. ANN NEUROL 2019.

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