Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia

Dora Fabbro, Angela V. D'Elia, Riccardo Spizzo, Lorenza Driul, Giovanni Barillari, Carla Di Loreto, Diego Marchesoni, Giuseppe Damante

Research output: Contribution to journalArticle

Abstract

It is known that the plasminogen activator inhibitor 1 (PAI-1) protein levels are increased in placentas of preeclamptic subjects. Therefore, we assessed whether polymorphisms related to the transcriptional control of the PAI-1 gene (-675 4G/5G and -844G/A) are associated with mild preeclampsia. We compared 52 women with preeclampsia to 80 women with a normal pregnancy. None of the preeclamptic women suffered from the severe form of preeclampsia. DNA was extracted from blood, and -675 4G/5G and -844G/A genotypes of the PAI-1 gene were determined. Since it has been shown that the presence of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene variants may be associated with preeclampsia, their frequency was also evaluated in our study groups. The factor V Leiden, PT G20210A, and MTHFR C677T gene variants were not associated with preeclampsia. In the case of the -675 4G/5G polymorphism, genotypes 4G/4G and 5G/5G were more prevalent in the preeclamptic and in the control group, respectively. In the case of -844 G/A polymorphism, genotypes A/A and G/G were more prevalent in the preeclamptic and in the control group, respectively. By using the χ2 test for trend, differences for both genotypes were significant (p = 0.0141 for the -675 genotypes and p = 0.0492 for the -844 genotypes). The frequency of the 4G and 5G alleles of the -675 gene polymorphism was significantly different between preeclamptic and normal women (p = 0.032). Differently, the allelic frequency of the -844 gene polymorphism did not show significant differences between preeclamptic and normal women (p = 0.083). In conclusion, the hypofibrinolytic genotypes 4G/4G and A/A at positions -675 and -844 of the PAI-1 gene are associated with the occurrence of mild preeclampsia independently of thrombophilic mutations of the factor V, prothrombin, and MTHFR genes.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume56
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • Gene polymorphisms
  • PAI-1
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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  • Cite this

    Fabbro, D., D'Elia, A. V., Spizzo, R., Driul, L., Barillari, G., Di Loreto, C., Marchesoni, D., & Damante, G. (2003). Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia. Gynecologic and Obstetric Investigation, 56(1), 17-22. https://doi.org/10.1159/000072326