Association between polymorphisms in the TNF region and systemic lupus erythematosus in the Italian population

S. D'Alfonso, G. Colombo, S. Della Bella, R. Scorza, P. Momigliano-Richiardi

Research output: Contribution to journalArticle

Abstract

The purpose of this work was to test the hypothesis that MHC encoded susceptibility factors for SLE lie in the TNF region. An association study was performed by analyzing 123 northern Italian SLE patients and 199 matched controls for three TNF markers: two polymorphisms in the TNFA promoter and the TNFa microsatellite. Haplotypic combinations of TNF markers were also compared in patients and controls. No significant association was observed considering either the whole SLE panel or SLE clinical and immunological subtypes. Three TNF-238/A homozygous patients were detected, while no homozygote was present in controls. The clinical and immunological phenotype of the three -238/A homozygotes suggests that the -238/AA genotype is a marker of a particular clinical subtype.

Original languageEnglish
Pages (from-to)551-555
Number of pages5
JournalTissue Antigens
Volume47
Issue number6
Publication statusPublished - 1996

Keywords

  • Disease susceptibility
  • Genetic association
  • Italian population
  • Polymorphism
  • Systemic lupus erythematosus
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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