Association between polymorphisms of the renin angiotensin system and carotid stenosis

Elena Sticchi, Ilaria Romagnuolo, Francesco Sofi, Giovanni Pratesi, Raffaele Pulli, Carlo Pratesi, Rosanna Abbate, Cinzia Fatini

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Carotid stenosis is a common manifestation of systemic atherosclerosis. Apart from traditional risk factors, genetic determinants, such as polymorphisms of the renin angiotensin system (RAS), may be relevant in modulating the atherosclerotic process leading to carotid stenosis. In this study, we investigated the role of angiotensin-converting enzyme (ACE) I/D and -240A>T, angiotensinogen (AGT) M235T, and angiotensin type 1 receptor (AGTR1) 1166A > C polymorphisms in modulating the susceptibility to the disease. Methods: Eight hundred twenty-one consecutive patients with severe carotid stenosis (

Original languageEnglish
Pages (from-to)467-473
Number of pages7
JournalJournal of Vascular Surgery
Volume54
Issue number2
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Carotid Stenosis
Renin-Angiotensin System
Angiotensinogen
Angiotensin Type 1 Receptor
Disease Susceptibility
Peptidyl-Dipeptidase A
Atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Association between polymorphisms of the renin angiotensin system and carotid stenosis. / Sticchi, Elena; Romagnuolo, Ilaria; Sofi, Francesco; Pratesi, Giovanni; Pulli, Raffaele; Pratesi, Carlo; Abbate, Rosanna; Fatini, Cinzia.

In: Journal of Vascular Surgery, Vol. 54, No. 2, 08.2011, p. 467-473.

Research output: Contribution to journalArticle

Sticchi, E, Romagnuolo, I, Sofi, F, Pratesi, G, Pulli, R, Pratesi, C, Abbate, R & Fatini, C 2011, 'Association between polymorphisms of the renin angiotensin system and carotid stenosis', Journal of Vascular Surgery, vol. 54, no. 2, pp. 467-473. https://doi.org/10.1016/j.jvs.2011.01.039
Sticchi, Elena ; Romagnuolo, Ilaria ; Sofi, Francesco ; Pratesi, Giovanni ; Pulli, Raffaele ; Pratesi, Carlo ; Abbate, Rosanna ; Fatini, Cinzia. / Association between polymorphisms of the renin angiotensin system and carotid stenosis. In: Journal of Vascular Surgery. 2011 ; Vol. 54, No. 2. pp. 467-473.
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