Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study.

Mazda Jenab, H. Bas Bueno-de-Mesquita, Pietro Ferrari, Franzel J B van Duijnhoven, Teresa Norat, Tobias Pischon, Eugène H J M Jansen, Nadia Slimani, Graham Byrnes, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Sophie Morois, Rudolf Kaaks, Jakob Linseisen, Heiner Boeing, Manuela M. BergmannAntonia Trichopoulou, Gesthimani Misirli, Dimitrios Trichopoulos, Franco Berrino, Paolo Vineis, Salvatore Panico, Domenico Palli, Rosario Tumino, Martine M. Ros, Carla H. van Gils, Petra H. Peeters, Magritt Brustad, Eiliv Lund, María José Tormo, Eva Ardanaz, Laudina Rodríguez, Maria José Sánchez, Miren Dorronsoro, Carlos A. Gonzalez, Göran Hallmans, Richard Palmqvist, Andrew Roddam, Timothy J. Key, Kay Tee Khaw, Philippe Autier, Pierre Hainaut, Elio Riboli

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations. DESIGN: Nested case-control study. Setting The study was conducted within the EPIC study, a cohort of more than 520 000 participants from 10 western European countries. PARTICIPANTS: 1248 cases of incident colorectal cancer, which developed after enrolment into the cohort, were matched to 1248 controls MAIN OUTCOME MEASURES: Circulating vitamin D concentration (25-hydroxy-vitamin-D, 25-(OH)D) was measured by enzyme immunoassay. Dietary and lifestyle data were obtained from questionnaires. Incidence rate ratios and 95% confidence intervals for the risk of colorectal cancer by 25-(OH)D concentration and levels of dietary calcium and vitamin D intake were estimated from multivariate conditional logistic regression models, with adjustment for potential dietary and other confounders. RESULTS: 25-(OH)D concentration showed a strong inverse linear dose-response association with risk of colorectal cancer (P for trend or=100.0 nmol/l: 0.77 (0.56 to 1.06)). In analyses by quintile of 25-(OH)D concentration, patients in the highest quintile had a 40% lower risk of colorectal cancer than did those in the lowest quintile (P

Original languageEnglish
JournalBritish Medical Journal
Volume340
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Medicine(all)

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