Association between resistin levels and all-cause and cardiovascular mortality: A new study and a systematic review and meta-analysis

Andrea Fontana, Sara Spadaro, Massimiliano Copetti, Belinda Spoto, Lucia Salvemini, Patrizia Pizzini, Lucia Frittitta, Francesca Mallamaci, Fabio Pellegrini, Vincenzo Trischitta, Claudia Menzaghi

Research output: Contribution to journalArticlepeer-review

Abstract

Context Studies concerning the association between circulating resistin and mortality risk have reported, so far, conflicting results. Objective To investigate the association between resistin and both all-cause and cardiovascular (CV) mortality risk by 1) analyzing data from the Gargano Heart Study (GHS) prospective design (n=359 patients; 81 and 58 all-cause and CV deaths, respectively); 2) performing metaanalyses of all published studies addressing the above mentioned associations. Data Source and Study Selection MEDLINE and Web of Science search of studies reporting hazard ratios (HR) of circulating resistin for all-cause or CV mortality. Data Extraction Performed independently by two investigators, using a standardized data extraction sheet. Data Synthesis In GHS, adjusted HRs per one standard deviation (SD) increment in resistin concentration were 1.28 (95% CI: 1.07-1.54) and 1.32 (95% CI: 1.06-1.64) for all-cause and CV mortality, respectively. The meta-analyses included 7 studies (n=4016; 961 events) for all-cause mortality and 6 studies (n=4,187: 412 events) for CV mortality. Pooled HRs per one SD increment in resistin levels were 1.21 (95% CI: 1.03-1.42, Q-test p for heterogeneity

Original languageEnglish
Article numbere0120419
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 20 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Association between resistin levels and all-cause and cardiovascular mortality: A new study and a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this