Association between restless legs syndrome and migraine: A population-based study

Stefano Zanigni, Giulia Giannini, Roberto Melotti, Cristian Pattaro, Federica Provini, Sabina Cevoli, Maurizio F. Facheris, Pietro Cortelli, Peter P. Pramstaller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and purpose: A higher prevalence of restless legs syndrome (RLS) in migraineurs has been reported in clinical samples and in two large-scale clinical trials performed on healthcare workers but general population-based studies on this topic are lacking. The aim of this study was to assess the association between migraine and RLS in an Italian rural adult population-based setting. Methods: The presence of migraine and RLS was assessed via a computer-assisted personal interview and self-administered questionnaires according to current diagnostic criteria in 1567 participants of a preliminary phase of an adult population-based study performed in South Tyrol, Italy. Results: Migraineurs had an increased risk of having RLS also after adjustment for confounding factors such as age, sex, major depression, anxiety and sleep quality (odds ratio 1.79; confidence interval 1.00-3.19; P = 0.049). This association was not modified by aura status and possible causes of secondary RLS. RLS was not significantly associated with tension-type headache. Conclusions: Restless legs syndrome and migraine were associated in our rural adult population. This association could be explained by a possible shared pathogenic pathway which would implicate new management strategies of these two disorders.

Original languageEnglish
Pages (from-to)1205-1210
Number of pages6
JournalEuropean Journal of Neurology
Volume21
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Restless Legs Syndrome
Migraine Disorders
Population
Rural Population
Tension-Type Headache
Microcomputers
Italy
Epilepsy
Sleep
Anxiety
Odds Ratio
Clinical Trials
Confidence Intervals
Interviews
Depression
Delivery of Health Care

Keywords

  • Comorbidity
  • Headache
  • Migraine
  • Restless legs syndrome
  • Sleep disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Association between restless legs syndrome and migraine : A population-based study. / Zanigni, Stefano; Giannini, Giulia; Melotti, Roberto; Pattaro, Cristian; Provini, Federica; Cevoli, Sabina; Facheris, Maurizio F.; Cortelli, Pietro; Pramstaller, Peter P.

In: European Journal of Neurology, Vol. 21, No. 9, 2014, p. 1205-1210.

Research output: Contribution to journalArticle

Zanigni, S, Giannini, G, Melotti, R, Pattaro, C, Provini, F, Cevoli, S, Facheris, MF, Cortelli, P & Pramstaller, PP 2014, 'Association between restless legs syndrome and migraine: A population-based study', European Journal of Neurology, vol. 21, no. 9, pp. 1205-1210. https://doi.org/10.1111/ene.12462
Zanigni, Stefano ; Giannini, Giulia ; Melotti, Roberto ; Pattaro, Cristian ; Provini, Federica ; Cevoli, Sabina ; Facheris, Maurizio F. ; Cortelli, Pietro ; Pramstaller, Peter P. / Association between restless legs syndrome and migraine : A population-based study. In: European Journal of Neurology. 2014 ; Vol. 21, No. 9. pp. 1205-1210.
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