Association between seasonal factors and multiple sclerosis

Abdulla Watad, Shir Azrielant, Alessandra Soriano, Danielle Bracco, Arsalan Abu Much, Howard Amital

Research output: Contribution to journalReview articlepeer-review

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system. MS is causing progressive and relapsing neurological disability, due to demyelination and axonal damage. The etiopathogenesis of MS is poorly understood. A number of environmental factors have been previously suggested, including: month of birth, vitamin D levels, smoking and viral infections. Previous studies assessing seasonal variation of relapses in multiple sclerosis have had conflicting results. The aim of this review is to assess the association between seasonal factors and MS, in terms of disease onset, relapses and activity.

Original languageEnglish
Pages (from-to)1081-1089
Number of pages9
JournalEuropean Journal of Epidemiology
Volume31
Issue number11
DOIs
Publication statusPublished - Nov 1 2016
Externally publishedYes

Keywords

  • Autoimmunity
  • Environment
  • Melatonin
  • Month of birth
  • Multiple sclerosis
  • Seasonality
  • Vitamin D

ASJC Scopus subject areas

  • Epidemiology

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