Association between serum carcinoembryonic antigen and endothelial cell adhesion molecules in colorectal cancer

Mario Roselli, Fiorella Guadagni, Francesca Martini, Antonella Spila, Sabrina Mariotti, Roberta D'Alessandro, Simona Aloe, Pier Paolo Gazzaniga, Stefania Basili, Maurizio Cosimelli, Patrizia Ferroni

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: To analyse the behaviour of pre-surgical serum levels of soluble (s)E-selectin and vascular cell adhesion molecule (sVCAM) in patients with colorectal cancer, and to evaluate their possible correlation with carcinoembryonic antigen (CEA), pro-inflammatory cytokines and clinicopathological features with respect to their prognostic value in predicting metastatic disease. Methods: Pre-surgical serum levels of sE-selectin, sVCAM, interleukin-6 (IL-6), IL-1β, tumour necrosis factor-α (TNF-α) and CEA were measured in 194 patients with colorectal adenocarcinoma, 40 patients with benign colorectal diseases and 59 healthy subjects. Results: sE-selectin, sVCAM, TNF-α and IL-6 levels were significantly higher in patients with colorectal cancer compared to either healthy subjects or patients with benign disease. Positive rates of sE-selectin, sVCAM and TNF-α levels were significantly associated with Dukes' stage D colorectal cancer, and all three variables were independently associated to the presence of distant metastases. Positive sE-selectin, sVCAM and TNF-α levels were significantly associated to CEA. TNF-α and CEA levels were independently related to the presence of positive levels of sE-selectin and/or sVCAM. Conclusions: Our findings suggest that the host inflammatory response to cancer cells, and/or their released products (i.e. CEA), might be responsible (via cytokine release) for the elevation in circulating adhesion molecules in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalOncology
Volume65
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

E-Selectin
Vascular Cell Adhesion Molecule-1
Carcinoembryonic Antigen
Cell Adhesion Molecules
Selectins
Colorectal Neoplasms
Endothelial Cells
Tumor Necrosis Factor-alpha
Serum
Interleukin-6
Healthy Volunteers
Cytokines
Interleukin-1
Adenocarcinoma
Neoplasm Metastasis
Neoplasms

Keywords

  • Adhesion
  • Colorectal cancer
  • E-selectin, soluble
  • Interleukin-6
  • Metastasis
  • Tumour necrosis factor-α
  • Vascular cell adhesion molecule-1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Association between serum carcinoembryonic antigen and endothelial cell adhesion molecules in colorectal cancer. / Roselli, Mario; Guadagni, Fiorella; Martini, Francesca; Spila, Antonella; Mariotti, Sabrina; D'Alessandro, Roberta; Aloe, Simona; Gazzaniga, Pier Paolo; Basili, Stefania; Cosimelli, Maurizio; Ferroni, Patrizia.

In: Oncology, Vol. 65, No. 2, 2003, p. 132-138.

Research output: Contribution to journalArticle

Roselli, M, Guadagni, F, Martini, F, Spila, A, Mariotti, S, D'Alessandro, R, Aloe, S, Gazzaniga, PP, Basili, S, Cosimelli, M & Ferroni, P 2003, 'Association between serum carcinoembryonic antigen and endothelial cell adhesion molecules in colorectal cancer', Oncology, vol. 65, no. 2, pp. 132-138. https://doi.org/10.1159/000072338
Roselli, Mario ; Guadagni, Fiorella ; Martini, Francesca ; Spila, Antonella ; Mariotti, Sabrina ; D'Alessandro, Roberta ; Aloe, Simona ; Gazzaniga, Pier Paolo ; Basili, Stefania ; Cosimelli, Maurizio ; Ferroni, Patrizia. / Association between serum carcinoembryonic antigen and endothelial cell adhesion molecules in colorectal cancer. In: Oncology. 2003 ; Vol. 65, No. 2. pp. 132-138.
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AU - Roselli, Mario

AU - Guadagni, Fiorella

AU - Martini, Francesca

AU - Spila, Antonella

AU - Mariotti, Sabrina

AU - D'Alessandro, Roberta

AU - Aloe, Simona

AU - Gazzaniga, Pier Paolo

AU - Basili, Stefania

AU - Cosimelli, Maurizio

AU - Ferroni, Patrizia

PY - 2003

Y1 - 2003

N2 - Objectives: To analyse the behaviour of pre-surgical serum levels of soluble (s)E-selectin and vascular cell adhesion molecule (sVCAM) in patients with colorectal cancer, and to evaluate their possible correlation with carcinoembryonic antigen (CEA), pro-inflammatory cytokines and clinicopathological features with respect to their prognostic value in predicting metastatic disease. Methods: Pre-surgical serum levels of sE-selectin, sVCAM, interleukin-6 (IL-6), IL-1β, tumour necrosis factor-α (TNF-α) and CEA were measured in 194 patients with colorectal adenocarcinoma, 40 patients with benign colorectal diseases and 59 healthy subjects. Results: sE-selectin, sVCAM, TNF-α and IL-6 levels were significantly higher in patients with colorectal cancer compared to either healthy subjects or patients with benign disease. Positive rates of sE-selectin, sVCAM and TNF-α levels were significantly associated with Dukes' stage D colorectal cancer, and all three variables were independently associated to the presence of distant metastases. Positive sE-selectin, sVCAM and TNF-α levels were significantly associated to CEA. TNF-α and CEA levels were independently related to the presence of positive levels of sE-selectin and/or sVCAM. Conclusions: Our findings suggest that the host inflammatory response to cancer cells, and/or their released products (i.e. CEA), might be responsible (via cytokine release) for the elevation in circulating adhesion molecules in patients with colorectal cancer.

AB - Objectives: To analyse the behaviour of pre-surgical serum levels of soluble (s)E-selectin and vascular cell adhesion molecule (sVCAM) in patients with colorectal cancer, and to evaluate their possible correlation with carcinoembryonic antigen (CEA), pro-inflammatory cytokines and clinicopathological features with respect to their prognostic value in predicting metastatic disease. Methods: Pre-surgical serum levels of sE-selectin, sVCAM, interleukin-6 (IL-6), IL-1β, tumour necrosis factor-α (TNF-α) and CEA were measured in 194 patients with colorectal adenocarcinoma, 40 patients with benign colorectal diseases and 59 healthy subjects. Results: sE-selectin, sVCAM, TNF-α and IL-6 levels were significantly higher in patients with colorectal cancer compared to either healthy subjects or patients with benign disease. Positive rates of sE-selectin, sVCAM and TNF-α levels were significantly associated with Dukes' stage D colorectal cancer, and all three variables were independently associated to the presence of distant metastases. Positive sE-selectin, sVCAM and TNF-α levels were significantly associated to CEA. TNF-α and CEA levels were independently related to the presence of positive levels of sE-selectin and/or sVCAM. Conclusions: Our findings suggest that the host inflammatory response to cancer cells, and/or their released products (i.e. CEA), might be responsible (via cytokine release) for the elevation in circulating adhesion molecules in patients with colorectal cancer.

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KW - Tumour necrosis factor-α

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