Association between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease

Mariacristina Siotto, Ilaria Simonelli, Patrizio Pasqualetti, Stefania Mariani, Deborah Caprara, Serena Bucossi, Mariacarla Ventriglia, Rossana Molinario, Mirca Antenucci, Mauro Rongioletti, Paolo Maria Rossini, Rosanna Squitti

Research output: Contribution to journalArticle

Abstract

Meta-analyses demonstrate copper involvement in Alzheimer's disease (AD), and the systemic ceruloplasmin status in relation to copper is an emerging issue. To deepen this matter, we evaluated levels of ceruloplasmin concentration, ceruloplasmin activity, ceruloplasmin specific activity (eCp/iCp), copper, non-ceruloplasmin copper iron, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype in a sample of 84 AD patients and 58 healthy volunteers. From the univariate logistic analyses we found that ceruloplasmin concentration, eCp/iCp, copper, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype were significantly associated with the probability of AD. In the multivariable logistic regression analysis, we selected the best subset of biological predictors by the forward stepwise procedure. The analysis showed a decrease of the risk of having AD for eCp/iCp (p=0.001) and an increase of this risk for non-ceruloplasmin copper (p=0.008), age (p=0.001), and APOE-ε4 allele (p<0.001). The estimated model showed a good power in discriminating AD patients from healthy controls (area under curve: 88; sensitivity: 66; specificity 93). These data strength the breakdown of copper homeostasis and propose eCp/iCp as a reliable marker of ceruloplasmin status.

Original languageEnglish
Pages (from-to)1181-1189
Number of pages9
JournalJournal of Alzheimer's Disease
Volume50
Issue number4
DOIs
Publication statusPublished - Feb 22 2016

Keywords

  • Alzheimer's disease
  • ceruloplasmin
  • ceruloplasmin specific activity
  • non-ceruloplasmin copper

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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  • Cite this

    Siotto, M., Simonelli, I., Pasqualetti, P., Mariani, S., Caprara, D., Bucossi, S., Ventriglia, M., Molinario, R., Antenucci, M., Rongioletti, M., Rossini, P. M., & Squitti, R. (2016). Association between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease. Journal of Alzheimer's Disease, 50(4), 1181-1189. https://doi.org/10.3233/JAD-150611