Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: Data from the Brisighella Heart Study

Arrigo F G Cicero, Paolo Salvi, Sergio D'Addato, Martina Rosticci, Claudio Borghi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. The aim of our study was to verify in a large well characterized population sample the relationship between SUA values, hypertension, arterial stiffness and subclinical atherosclerosis. METHODS: For this study, we selected 248 men and 371 women adult patients enrolled in the last Brisighella Heart Study population survey for which a full set of data were available and not consuming antihypertensive, antidiabetic, lipid-lowering and uric acid-lowering drugs. SUA and other available variables were related to blood pressure level, carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT). RESULTS: Hypertension prevalence was strongly related to SUA quartiles: we found significant differences between the 2nd (23.0%) and the 3rd quartiles (36.4%; P vs. 2nd

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalJournal of Hypertension
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Hypertension
  • Intima-media thickness
  • Pulse wave velocity
  • Serum uric acid

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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