Association between sex, systemic iron variation and probability of Parkinson's disease

S. Mariani, M. Ventriglia, I. Simonelli, S. Bucossi, M. Siotto, S. Donno, F. Vernieri, R. Squitti

Research output: Contribution to journalArticle

Abstract

Objective: Iron homeostasis appears altered in Parkinson's disease (PD). Recent genetic studies and meta-analyses have produced heterogeneous and inconclusive results. In order to verify the possible role of iron status in PD, we have screened some of the main metal gene variants, evaluated their effects on iron systemic status, and checked for possible interactions with PD. Materials and methods: In 92 PD patients and 112 healthy controls, we screened the D544E and R793H variants of the ceruloplasmin gene (CP), the P589S variant of the transferrin gene (TF), and the H63D and C282Y variants of the HFE gene, encoding for homologous proteins, respectively. Furthermore, we analyzed serum concentrations of iron, copper and their related proteins. Results: The genetic investigation revealed no significant differences in allelic and genotype distributions between patients and controls. Two different multivariable forward stepwise logistic models showed that, when the effect of sex is considered, an increase of the probability of having PD is associated with low iron concentration and Tf-saturation. Conclusions: This study provides new evidence of the involvement of iron metabolism in PD pathogenesis and reveals a biological effect of sex.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalInternational Journal of Neuroscience
Volume126
Issue number4
DOIs
Publication statusPublished - Apr 2 2016

Fingerprint

Parkinson Disease
Iron
Genes
Ceruloplasmin
Transferrin
Meta-Analysis
Copper
Proteins
Homeostasis
Logistic Models
Metals
Genotype
Serum

Keywords

  • ceruloplasmin
  • CP
  • HFE
  • iron
  • Parkinson's disease
  • PD
  • transferrin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Association between sex, systemic iron variation and probability of Parkinson's disease. / Mariani, S.; Ventriglia, M.; Simonelli, I.; Bucossi, S.; Siotto, M.; Donno, S.; Vernieri, F.; Squitti, R.

In: International Journal of Neuroscience, Vol. 126, No. 4, 02.04.2016, p. 354-360.

Research output: Contribution to journalArticle

Mariani, S, Ventriglia, M, Simonelli, I, Bucossi, S, Siotto, M, Donno, S, Vernieri, F & Squitti, R 2016, 'Association between sex, systemic iron variation and probability of Parkinson's disease', International Journal of Neuroscience, vol. 126, no. 4, pp. 354-360. https://doi.org/10.3109/00207454.2015.1020113
Mariani, S. ; Ventriglia, M. ; Simonelli, I. ; Bucossi, S. ; Siotto, M. ; Donno, S. ; Vernieri, F. ; Squitti, R. / Association between sex, systemic iron variation and probability of Parkinson's disease. In: International Journal of Neuroscience. 2016 ; Vol. 126, No. 4. pp. 354-360.
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