Abstract
Objective: Iron homeostasis appears altered in Parkinson's disease (PD). Recent genetic studies and meta-analyses have produced heterogeneous and inconclusive results. In order to verify the possible role of iron status in PD, we have screened some of the main metal gene variants, evaluated their effects on iron systemic status, and checked for possible interactions with PD. Materials and methods: In 92 PD patients and 112 healthy controls, we screened the D544E and R793H variants of the ceruloplasmin gene (CP), the P589S variant of the transferrin gene (TF), and the H63D and C282Y variants of the HFE gene, encoding for homologous proteins, respectively. Furthermore, we analyzed serum concentrations of iron, copper and their related proteins. Results: The genetic investigation revealed no significant differences in allelic and genotype distributions between patients and controls. Two different multivariable forward stepwise logistic models showed that, when the effect of sex is considered, an increase of the probability of having PD is associated with low iron concentration and Tf-saturation. Conclusions: This study provides new evidence of the involvement of iron metabolism in PD pathogenesis and reveals a biological effect of sex.
| Original language | English |
|---|---|
| Pages (from-to) | 354-360 |
| Number of pages | 7 |
| Journal | International Journal of Neuroscience |
| Volume | 126 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2 2016 |
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Keywords
- ceruloplasmin
- CP
- HFE
- iron
- Parkinson's disease
- PD
- transferrin
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Association between sex, systemic iron variation and probability of Parkinson's disease. / Mariani, S.; Ventriglia, M.; Simonelli, I.; Bucossi, S.; Siotto, M.; Donno, S.; Vernieri, F.; Squitti, R.
In: International Journal of Neuroscience, Vol. 126, No. 4, 02.04.2016, p. 354-360.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between sex, systemic iron variation and probability of Parkinson's disease
AU - Mariani, S.
AU - Ventriglia, M.
AU - Simonelli, I.
AU - Bucossi, S.
AU - Siotto, M.
AU - Donno, S.
AU - Vernieri, F.
AU - Squitti, R.
PY - 2016/4/2
Y1 - 2016/4/2
N2 - Objective: Iron homeostasis appears altered in Parkinson's disease (PD). Recent genetic studies and meta-analyses have produced heterogeneous and inconclusive results. In order to verify the possible role of iron status in PD, we have screened some of the main metal gene variants, evaluated their effects on iron systemic status, and checked for possible interactions with PD. Materials and methods: In 92 PD patients and 112 healthy controls, we screened the D544E and R793H variants of the ceruloplasmin gene (CP), the P589S variant of the transferrin gene (TF), and the H63D and C282Y variants of the HFE gene, encoding for homologous proteins, respectively. Furthermore, we analyzed serum concentrations of iron, copper and their related proteins. Results: The genetic investigation revealed no significant differences in allelic and genotype distributions between patients and controls. Two different multivariable forward stepwise logistic models showed that, when the effect of sex is considered, an increase of the probability of having PD is associated with low iron concentration and Tf-saturation. Conclusions: This study provides new evidence of the involvement of iron metabolism in PD pathogenesis and reveals a biological effect of sex.
AB - Objective: Iron homeostasis appears altered in Parkinson's disease (PD). Recent genetic studies and meta-analyses have produced heterogeneous and inconclusive results. In order to verify the possible role of iron status in PD, we have screened some of the main metal gene variants, evaluated their effects on iron systemic status, and checked for possible interactions with PD. Materials and methods: In 92 PD patients and 112 healthy controls, we screened the D544E and R793H variants of the ceruloplasmin gene (CP), the P589S variant of the transferrin gene (TF), and the H63D and C282Y variants of the HFE gene, encoding for homologous proteins, respectively. Furthermore, we analyzed serum concentrations of iron, copper and their related proteins. Results: The genetic investigation revealed no significant differences in allelic and genotype distributions between patients and controls. Two different multivariable forward stepwise logistic models showed that, when the effect of sex is considered, an increase of the probability of having PD is associated with low iron concentration and Tf-saturation. Conclusions: This study provides new evidence of the involvement of iron metabolism in PD pathogenesis and reveals a biological effect of sex.
KW - ceruloplasmin
KW - CP
KW - HFE
KW - iron
KW - Parkinson's disease
KW - PD
KW - transferrin
UR - http://www.scopus.com/inward/record.url?scp=84954285006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954285006&partnerID=8YFLogxK
U2 - 10.3109/00207454.2015.1020113
DO - 10.3109/00207454.2015.1020113
M3 - Article
AN - SCOPUS:84954285006
VL - 126
SP - 354
EP - 360
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
SN - 0020-7454
IS - 4
ER -