Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans

Enzo Emanuele, Emmanouil Peros, Carmine Tomaino, Enrica Feudatari, Livia Bernardi, Giuliano Binetti, Raffaele Maletta, Giuseppe Micieli, Amalia Cecilia Bruni, Diego Geroldi

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Abstract

Apolipoprotein(a) [apo(a)] is a genetically polymorphic glycoprotein that has several similarities to apolipoprotein E. However, its role as a risk factor for frontotemporal dementia (FTD) remains to be elucidated. We therefore investigated the effect of an apo(a) polymorphism on the incidence of FTD in a sample of Caucasian Italian patients. From the entire group of FTD patients (n=54), 55.6% of the subjects had at least one apo(a) low molecular weight (MW) isoform, compared to 29.9% of non-demented controls (n=77). The difference between the two groups was statistically significant (odds ratio 2.93, 95% confidence interval 1.42-6.06, P=0.003). The FTD group was further divided into sporadic (n=26) and familial (n=28) cases. Even after such dichotomization, both sporadic and familial FTD patients showed a significantly higher prevalence of low MW apo(a) isoforms than the cognitively healthy controls (P=0.011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalNeuroscience Letters
Volume353
Issue number3
DOIs
Publication statusPublished - Dec 26 2003

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Keywords

  • Apolipoprotein(a) isoforms
  • Biomarkers
  • Frontotemporal dementia
  • Susceptibility

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Emanuele, E., Peros, E., Tomaino, C., Feudatari, E., Bernardi, L., Binetti, G., Maletta, R., Micieli, G., Bruni, A. C., & Geroldi, D. (2003). Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans. Neuroscience Letters, 353(3), 201-204. https://doi.org/10.1016/j.neulet.2003.09.046