TY - JOUR
T1 - Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans
AU - Emanuele, Enzo
AU - Peros, Emmanouil
AU - Tomaino, Carmine
AU - Feudatari, Enrica
AU - Bernardi, Livia
AU - Binetti, Giuliano
AU - Maletta, Raffaele
AU - Micieli, Giuseppe
AU - Bruni, Amalia Cecilia
AU - Geroldi, Diego
PY - 2003/12/26
Y1 - 2003/12/26
N2 - Apolipoprotein(a) [apo(a)] is a genetically polymorphic glycoprotein that has several similarities to apolipoprotein E. However, its role as a risk factor for frontotemporal dementia (FTD) remains to be elucidated. We therefore investigated the effect of an apo(a) polymorphism on the incidence of FTD in a sample of Caucasian Italian patients. From the entire group of FTD patients (n=54), 55.6% of the subjects had at least one apo(a) low molecular weight (MW) isoform, compared to 29.9% of non-demented controls (n=77). The difference between the two groups was statistically significant (odds ratio 2.93, 95% confidence interval 1.42-6.06, P=0.003). The FTD group was further divided into sporadic (n=26) and familial (n=28) cases. Even after such dichotomization, both sporadic and familial FTD patients showed a significantly higher prevalence of low MW apo(a) isoforms than the cognitively healthy controls (P=0.011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD.
AB - Apolipoprotein(a) [apo(a)] is a genetically polymorphic glycoprotein that has several similarities to apolipoprotein E. However, its role as a risk factor for frontotemporal dementia (FTD) remains to be elucidated. We therefore investigated the effect of an apo(a) polymorphism on the incidence of FTD in a sample of Caucasian Italian patients. From the entire group of FTD patients (n=54), 55.6% of the subjects had at least one apo(a) low molecular weight (MW) isoform, compared to 29.9% of non-demented controls (n=77). The difference between the two groups was statistically significant (odds ratio 2.93, 95% confidence interval 1.42-6.06, P=0.003). The FTD group was further divided into sporadic (n=26) and familial (n=28) cases. Even after such dichotomization, both sporadic and familial FTD patients showed a significantly higher prevalence of low MW apo(a) isoforms than the cognitively healthy controls (P=0.011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD.
KW - Apolipoprotein(a) isoforms
KW - Biomarkers
KW - Frontotemporal dementia
KW - Susceptibility
UR - http://www.scopus.com/inward/record.url?scp=10744222283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744222283&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2003.09.046
DO - 10.1016/j.neulet.2003.09.046
M3 - Article
C2 - 14665416
AN - SCOPUS:10744222283
VL - 353
SP - 201
EP - 204
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -