Association between the dietary inflammatory index and breast cancer in a large Italian case–control study

N. Shivappa, J.R. Hébert, V. Rosato, M. Montella, D. Serraino, C. La Vecchia

Research output: Contribution to journalArticle

Abstract

Introduction: The putative relationship between diet, including its inflammatory potential, and breast cancer has been studied extensively, but results remain inconsistent. Using data from a large Italian case–control study conducted between 1991 and 1994, we examined the association between the dietary inflammatory index (DII) and odds of breast cancer. Methods: DII scores were computed using a validated 78-item food frequency questionnaire. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 controls admitted to hospital for acute, non-hormone-related diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) based on continuous and quintiles of DII were estimated by multiple logistic regression adjusting for age, study center, education, BMI, parity, menopausal status, family history of hormone-related cancers, and total energy intake. Results: Women in quintiles 2, 3, 4 and 5 had ORs of breast cancer of 1.33 (95% CI: 1.11, 1.59), 1.37 (95% CI: 1.13, 1.66), 1.41 (95% CI: 1.15, 1.73), and 1.75 (95% CI: 1.39, 2.21), respectively, compared to women in quintile 1. One-unit increase in DII increased the odds of having breast cancer by 9% (95% CI: 1.05, 1.14). Conclusions: A pro-inflammatory diet is associated to increased risk of breast cancer. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish
Article number1600500
Number of pages7
JournalMolecular Nutrition and Food Research
Volume61
Issue number3
DOIs
Publication statusPublished - 2017

Fingerprint

Inflammatory Breast Neoplasms
breast neoplasms
confidence interval
Confidence Intervals
Breast Neoplasms
odds ratio
Odds Ratio
Diet
menopause
food frequency questionnaires
parity (reproduction)
Parity
Energy Intake
diet
education
energy intake
Logistic Models
hormones
Hormones
Education

Keywords

  • Breast cancer
  • Case–control
  • Diet
  • DII
  • Italy
  • adult
  • aged
  • body mass
  • breast tumor
  • caloric intake
  • case control study
  • clinical trial
  • complication
  • diet
  • female
  • human
  • inflammation
  • menopause
  • middle aged
  • multicenter study
  • odds ratio
  • risk factor
  • Adult
  • Aged
  • Body Mass Index
  • Breast Neoplasms
  • Case-Control Studies
  • Energy Intake
  • Female
  • Humans
  • Inflammation
  • Menopause
  • Middle Aged
  • Odds Ratio
  • Risk Factors

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Association between the dietary inflammatory index and breast cancer in a large Italian case–control study. / Shivappa, N.; Hébert, J.R.; Rosato, V.; Montella, M.; Serraino, D.; La Vecchia, C.

In: Molecular Nutrition and Food Research, Vol. 61, No. 3, 1600500, 2017.

Research output: Contribution to journalArticle

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abstract = "Introduction: The putative relationship between diet, including its inflammatory potential, and breast cancer has been studied extensively, but results remain inconsistent. Using data from a large Italian case–control study conducted between 1991 and 1994, we examined the association between the dietary inflammatory index (DII) and odds of breast cancer. Methods: DII scores were computed using a validated 78-item food frequency questionnaire. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 controls admitted to hospital for acute, non-hormone-related diseases. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) based on continuous and quintiles of DII were estimated by multiple logistic regression adjusting for age, study center, education, BMI, parity, menopausal status, family history of hormone-related cancers, and total energy intake. Results: Women in quintiles 2, 3, 4 and 5 had ORs of breast cancer of 1.33 (95{\%} CI: 1.11, 1.59), 1.37 (95{\%} CI: 1.13, 1.66), 1.41 (95{\%} CI: 1.15, 1.73), and 1.75 (95{\%} CI: 1.39, 2.21), respectively, compared to women in quintile 1. One-unit increase in DII increased the odds of having breast cancer by 9{\%} (95{\%} CI: 1.05, 1.14). Conclusions: A pro-inflammatory diet is associated to increased risk of breast cancer. {\circledC} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
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author = "N. Shivappa and J.R. H{\'e}bert and V. Rosato and M. Montella and D. Serraino and {La Vecchia}, C.",
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T1 - Association between the dietary inflammatory index and breast cancer in a large Italian case–control study

AU - Shivappa, N.

AU - Hébert, J.R.

AU - Rosato, V.

AU - Montella, M.

AU - Serraino, D.

AU - La Vecchia, C.

N1 - Cited By :2 Export Date: 14 February 2018 Correspondence Address: Shivappa, N.; Cancer Prevention and Control Program, University of South CarolinaUnited States; email: shivappa@mailbox.sc.edu

PY - 2017

Y1 - 2017

N2 - Introduction: The putative relationship between diet, including its inflammatory potential, and breast cancer has been studied extensively, but results remain inconsistent. Using data from a large Italian case–control study conducted between 1991 and 1994, we examined the association between the dietary inflammatory index (DII) and odds of breast cancer. Methods: DII scores were computed using a validated 78-item food frequency questionnaire. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 controls admitted to hospital for acute, non-hormone-related diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) based on continuous and quintiles of DII were estimated by multiple logistic regression adjusting for age, study center, education, BMI, parity, menopausal status, family history of hormone-related cancers, and total energy intake. Results: Women in quintiles 2, 3, 4 and 5 had ORs of breast cancer of 1.33 (95% CI: 1.11, 1.59), 1.37 (95% CI: 1.13, 1.66), 1.41 (95% CI: 1.15, 1.73), and 1.75 (95% CI: 1.39, 2.21), respectively, compared to women in quintile 1. One-unit increase in DII increased the odds of having breast cancer by 9% (95% CI: 1.05, 1.14). Conclusions: A pro-inflammatory diet is associated to increased risk of breast cancer. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - Introduction: The putative relationship between diet, including its inflammatory potential, and breast cancer has been studied extensively, but results remain inconsistent. Using data from a large Italian case–control study conducted between 1991 and 1994, we examined the association between the dietary inflammatory index (DII) and odds of breast cancer. Methods: DII scores were computed using a validated 78-item food frequency questionnaire. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 controls admitted to hospital for acute, non-hormone-related diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) based on continuous and quintiles of DII were estimated by multiple logistic regression adjusting for age, study center, education, BMI, parity, menopausal status, family history of hormone-related cancers, and total energy intake. Results: Women in quintiles 2, 3, 4 and 5 had ORs of breast cancer of 1.33 (95% CI: 1.11, 1.59), 1.37 (95% CI: 1.13, 1.66), 1.41 (95% CI: 1.15, 1.73), and 1.75 (95% CI: 1.39, 2.21), respectively, compared to women in quintile 1. One-unit increase in DII increased the odds of having breast cancer by 9% (95% CI: 1.05, 1.14). Conclusions: A pro-inflammatory diet is associated to increased risk of breast cancer. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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KW - Humans

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JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

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