Abstract
Objective: To investigate the association between tumor diameter and intratumoral risk factors thatmight predict the need for full surgical staging among womenwith endometrial cancer (EC). Methods: Data frompatients with early-stage EC treated at the Istituto Nazionale dei Tumori, Milan, Italy, between January 2004 and December 2012 were retrospectively analyzed. Associations between tumor diameter and tumor grade, myometrial invasion, risk group, lymphovascular space invasion (LVSI), and lower uterine segment (LUS) involvement were assessed by bivariate and multivariate analysis. Results: In total, 181 patients met the inclusion criteria. The tumor diameterwas 2 cmor less in 110 women (60%). χ2 analysis showed that tumor grading,myometrial invasion, risk group, and LVSI were significantly associated with tumor size (P <0.001), whereas LUS involvement was marginally associated (P = 0.051). By multivariate analysis, LVSI and myometrial invasion had an independent association with tumor size greater than 2 cm (P <0.018). Conclusion: Tumor size greater than 2 cm was significantly and independently associated with LVSI and myometrial invasion among patients with earlystage EC. Given the difficulty of obtaining reliable LVSI data from frozen sections, tumor size might be used as a surrogate at the time of surgery to provide additional information to triage patients for full surgical staging.
| Original language | English |
|---|---|
| Pages (from-to) | 142-145 |
| Number of pages | 4 |
| Journal | International Journal of Gynecology and Obstetrics |
| Volume | 123 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Endometrial cancer
- Lymphovascular space invasion
- Risk stratification
- Tumor diameter
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer. / Laufer, Joel; Scasso, Santiago; Papadia, Andrea; Sosa, Claudio; Cirillo, Federico; Raspagliesi, Francesco.
In: International Journal of Gynecology and Obstetrics, Vol. 123, No. 2, 11.2013, p. 142-145.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between tumor diameter and lymphovascular space invasion among women with early-stage endometrial cancer
AU - Laufer, Joel
AU - Scasso, Santiago
AU - Papadia, Andrea
AU - Sosa, Claudio
AU - Cirillo, Federico
AU - Raspagliesi, Francesco
PY - 2013/11
Y1 - 2013/11
N2 - Objective: To investigate the association between tumor diameter and intratumoral risk factors thatmight predict the need for full surgical staging among womenwith endometrial cancer (EC). Methods: Data frompatients with early-stage EC treated at the Istituto Nazionale dei Tumori, Milan, Italy, between January 2004 and December 2012 were retrospectively analyzed. Associations between tumor diameter and tumor grade, myometrial invasion, risk group, lymphovascular space invasion (LVSI), and lower uterine segment (LUS) involvement were assessed by bivariate and multivariate analysis. Results: In total, 181 patients met the inclusion criteria. The tumor diameterwas 2 cmor less in 110 women (60%). χ2 analysis showed that tumor grading,myometrial invasion, risk group, and LVSI were significantly associated with tumor size (P <0.001), whereas LUS involvement was marginally associated (P = 0.051). By multivariate analysis, LVSI and myometrial invasion had an independent association with tumor size greater than 2 cm (P <0.018). Conclusion: Tumor size greater than 2 cm was significantly and independently associated with LVSI and myometrial invasion among patients with earlystage EC. Given the difficulty of obtaining reliable LVSI data from frozen sections, tumor size might be used as a surrogate at the time of surgery to provide additional information to triage patients for full surgical staging.
AB - Objective: To investigate the association between tumor diameter and intratumoral risk factors thatmight predict the need for full surgical staging among womenwith endometrial cancer (EC). Methods: Data frompatients with early-stage EC treated at the Istituto Nazionale dei Tumori, Milan, Italy, between January 2004 and December 2012 were retrospectively analyzed. Associations between tumor diameter and tumor grade, myometrial invasion, risk group, lymphovascular space invasion (LVSI), and lower uterine segment (LUS) involvement were assessed by bivariate and multivariate analysis. Results: In total, 181 patients met the inclusion criteria. The tumor diameterwas 2 cmor less in 110 women (60%). χ2 analysis showed that tumor grading,myometrial invasion, risk group, and LVSI were significantly associated with tumor size (P <0.001), whereas LUS involvement was marginally associated (P = 0.051). By multivariate analysis, LVSI and myometrial invasion had an independent association with tumor size greater than 2 cm (P <0.018). Conclusion: Tumor size greater than 2 cm was significantly and independently associated with LVSI and myometrial invasion among patients with earlystage EC. Given the difficulty of obtaining reliable LVSI data from frozen sections, tumor size might be used as a surrogate at the time of surgery to provide additional information to triage patients for full surgical staging.
KW - Endometrial cancer
KW - Lymphovascular space invasion
KW - Risk stratification
KW - Tumor diameter
UR - http://www.scopus.com/inward/record.url?scp=84885176114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885176114&partnerID=8YFLogxK
U2 - 10.1016/j.ijgo.2013.05.012
DO - 10.1016/j.ijgo.2013.05.012
M3 - Article
C2 - 23954391
AN - SCOPUS:84885176114
VL - 123
SP - 142
EP - 145
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
SN - 0020-7292
IS - 2
ER -