Various clinical studies have been carried out in patients with PCP employing several pharmacological compounds and associations (TMP/dapsone, eflornithine, trimetrexate, atovaquone, clindamycin/primaquine) as possible therapeutic alternatives. In open and controlled studies clindamycin/primaquine has proved to be a valid alternative, especially in patients intolerant to cotrimoxazole and/or pentamidine. Six patients with HIV infection and moderately serious pneumocystosis have been treated. Four of them were intolerant and two didn't respond to the treatment with cotrimoxazole. The therapeutic treatment has proved to be effective in 5/6 patients (83.3%), although the incidence of side-effects is quite high and quite serious in two patients.
|Translated title of the contribution||Association clindamycin/primaquine in the therapy of Pneumocystis carinii pneumonia in patients with AIDS|
|Number of pages||3|
|Journal||Giornale di Malattie Infettive e Parassitarie|
|Publication status||Published - 1994|
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