ASSOCIAZIONE CLINDAMICINA/PRIMACHINA NELLA TERAPIA DELLA POLMONITE DA P. CARINII IN PAZIENTI CON AIDS

Translated title of the contribution: Association clindamycin/primaquine in the therapy of Pneumocystis carinii pneumonia in patients with AIDS

M. P. Sciotti, F. N. Lauria

Research output: Contribution to journalArticlepeer-review

Abstract

Various clinical studies have been carried out in patients with PCP employing several pharmacological compounds and associations (TMP/dapsone, eflornithine, trimetrexate, atovaquone, clindamycin/primaquine) as possible therapeutic alternatives. In open and controlled studies clindamycin/primaquine has proved to be a valid alternative, especially in patients intolerant to cotrimoxazole and/or pentamidine. Six patients with HIV infection and moderately serious pneumocystosis have been treated. Four of them were intolerant and two didn't respond to the treatment with cotrimoxazole. The therapeutic treatment has proved to be effective in 5/6 patients (83.3%), although the incidence of side-effects is quite high and quite serious in two patients.

Translated title of the contributionAssociation clindamycin/primaquine in the therapy of Pneumocystis carinii pneumonia in patients with AIDS
Original languageItalian
Pages (from-to)1011-1013
Number of pages3
JournalGiornale di Malattie Infettive e Parassitarie
Volume46
Issue number11
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Parasitology

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