Association of 6q deletions with AIDS-related diffuse large cell lymphoma

C. Pastore, A. Carbone, A. Gloghini, G. Volpe, G. Saglio, G. Gaidano

Research output: Contribution to journalArticlepeer-review

Abstract

Deletions of chromosome 6 at band q27 represent the site of a putative novel tumor suppressor gene in non-Hodgkin's lymphomas (NHL) of the immunocompetent host. Although several genetic lesions have been identified in AIDS-related NHL (AIDS-NHL), the involvement of 6q27 loss has not been investigated in this NHL category. In this report, we tested the presence of a 6q deletion at the molecular level in a panel of AIDS-NHL representative of the major histologic types, including AIDS-related small non-cleaved cell lymphoma (AIDS-SNCCL; n = 10), AIDS-related diffuse large cell lymphoma (AIDS-DLCL; n = 13) and AIDS related anaplastic large cell lymphoma (AIDS-ALCL; n = 3). We report that 6q deletions occur in 5/26 AIDS-NHL tested (19.2%). Notably, 6q deletions do not randomly distribute throughout the spectrum of AIDS NHL histologic types, but rather selectively cluster with AIDS-DLCL (5/13; 38.4%). Overall, these data add to the notion that the molecular pathogenesis of AIDS-NHL is heterogeneous and that distinct genetic pathways associate with specific histologic categories of AIDS-NHL.

Original languageEnglish
Pages (from-to)1051-1053
Number of pages3
JournalLeukemia
Volume10
Issue number6
Publication statusPublished - Jun 1996

Keywords

  • AIDS
  • Chromosome 6
  • Lymphoma
  • Tumor suppressor loci

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

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