Association of adiposity, dysmetabolisms, and inflammation with aggressive breast cancer subtypes: a cross-sectional study

Roberto Agresti, Elisabetta Meneghini, Paolo Baili, Pamela Minicozzi, Alberto Turco, Ilaria Cavallo, Francesco Funaro, Hade Amash, Franco Berrino, Elda Tagliabue, Milena Sant

Research output: Contribution to journalArticlepeer-review

Abstract

Obesity and metabolic syndrome are risk and prognostic factors for breast cancer (BC) and are associated with chronic inflammation. We investigated the association between distinct BC subtypes and markers of adiposity, dysmetabolisms, and inflammation. We analyzed 1779 patients with primary invasive BC treated at a single institution, for whom anthropometric and clinical-pathological data were archived. BC subtypes were classified by immunohistochemical staining of ER, PR, HER2, and Ki67, and their relations with the study markers were assessed by multinomial logistic regression. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated taking luminal A as reference. All subtypes more aggressive than luminal A were significantly more frequent in younger (

Original languageEnglish
Pages (from-to)179-189
Number of pages11
JournalBreast Cancer Research and Treatment
Volume157
Issue number1
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Adiposity
  • Breast cancer subtype
  • Inflammation
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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