TY - JOUR
T1 - Association of adiposity, dysmetabolisms, and inflammation with aggressive breast cancer subtypes
T2 - a cross-sectional study
AU - Agresti, Roberto
AU - Meneghini, Elisabetta
AU - Baili, Paolo
AU - Minicozzi, Pamela
AU - Turco, Alberto
AU - Cavallo, Ilaria
AU - Funaro, Francesco
AU - Amash, Hade
AU - Berrino, Franco
AU - Tagliabue, Elda
AU - Sant, Milena
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Obesity and metabolic syndrome are risk and prognostic factors for breast cancer (BC) and are associated with chronic inflammation. We investigated the association between distinct BC subtypes and markers of adiposity, dysmetabolisms, and inflammation. We analyzed 1779 patients with primary invasive BC treated at a single institution, for whom anthropometric and clinical-pathological data were archived. BC subtypes were classified by immunohistochemical staining of ER, PR, HER2, and Ki67, and their relations with the study markers were assessed by multinomial logistic regression. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated taking luminal A as reference. All subtypes more aggressive than luminal A were significantly more frequent in younger (
AB - Obesity and metabolic syndrome are risk and prognostic factors for breast cancer (BC) and are associated with chronic inflammation. We investigated the association between distinct BC subtypes and markers of adiposity, dysmetabolisms, and inflammation. We analyzed 1779 patients with primary invasive BC treated at a single institution, for whom anthropometric and clinical-pathological data were archived. BC subtypes were classified by immunohistochemical staining of ER, PR, HER2, and Ki67, and their relations with the study markers were assessed by multinomial logistic regression. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated taking luminal A as reference. All subtypes more aggressive than luminal A were significantly more frequent in younger (
KW - Adiposity
KW - Breast cancer subtype
KW - Inflammation
KW - Insulin resistance
KW - Metabolic syndrome
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U2 - 10.1007/s10549-016-3802-3
DO - 10.1007/s10549-016-3802-3
M3 - Article
AN - SCOPUS:84969509960
VL - 157
SP - 179
EP - 189
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 1
ER -