Association of alcohol consumption with HDL subpopulations defined by apolipoprotein A-I and apolipoprotein A-II content

A. Branchi, A. Rovellini, C. Tomella, L. Sciariada, A. Torri, M. Molgora, D. Sommariva

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the relationship between alcohol intake and serum level of high-density lipoprotein (HDL) subfractions defined on the basis of their apolipoprotein A-I and A-II content (LpA-I and LpA-I:A-II). Design: Observational study. Setting: Institute of Internal Medicine and Medical Physiopathology, IRCCS Maggiore Hospital, University of Milan. Subjects: One hundred healthy males with a mean age of 42 ± 11.1 y, selected among blood donors. Results: Both LpA-I and LpA-I:A-II were significantly higher in men drinking more than 30 g a day of alcohol than in non-drinkers (LpA-I: difference between means 6.5 mg/dL, 95% C.I. 1.14-11.9; LpA-I:A-II difference between means 11.5 mg/dL, 95% C.I. 0.52-22.5). The association of alcohol consumption with LpA-I and LpA-I:A-II levels was independent from age, body mass index, physical activity, serum triglycerides and diet composition. Conclusions: Alcohol consumption is associated with an increase of serum levels of both LpA-I and LpA-I:A-II particles and this may, at least in part, explain the reduced cardiovascular morbidity observed in subjects drinking moderate amounts of alcoholic beverages.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalEuropean Journal of Clinical Nutrition
Volume51
Issue number6
Publication statusPublished - Jun 1997

Keywords

  • Alcohol
  • Apolipoprotein A
  • HDL subfractions
  • HDL-cholesterol
  • LPA-I
  • LPA-I:AII

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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