Association of Alpha Tocopherol and Ag Sulfadiazine Chitosan Oleate Nanocarriers in Bioactive Dressings Supporting Platelet Lysate Application to Skin Wounds

Maria Cristina Bonferoni, Giuseppina Sandri, Silvia Rossi, Eleonora Dellera, Alessandro Invernizzi, Cinzia Boselli, Antonia Icaro Cornaglia, Claudia Del Fante, Cesare Perotti, Barbara Vigani, Federica Riva, Carla Caramella, Franca Ferrari

Research output: Contribution to journalArticle

Abstract

Chitosan oleate was previously proposed to encapsulate in nanocarriers some poorly soluble molecules aimed to wound therapy, such as the anti-infective silver sulfadiazine, and the antioxidant α tocopherol. Because nanocarriers need a suitable formulation to be administered to wounds, in the present paper, these previously developed nanocarriers were loaded into freeze dried dressings based on chitosan glutamate. These were proposed as bioactive dressings aimed to support the application to wounds of platelet lysate, a hemoderivative rich in growth factors. The dressings were characterized for hydration capacity, morphological aspect, and rheological and mechanical behavior. Although chitosan oleate nanocarriers clearly decreased the mechanical properties of dressings, these remained compatible with handling and application to wounds. Preliminary studies in vitro on fibroblast cell cultures demonstrated good compatibility of platelet lysate with nanocarriers and bioactive dressings. An in vivo study on a murine wound model showed an accelerating wound healing effect for the bioactive dressing and its suitability as support of the platelet lysate application to wounds.

Original languageEnglish
JournalMarine Drugs
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 9 2018

Keywords

  • Animals
  • Biological Dressings
  • Blood Platelets/chemistry
  • Cell Proliferation/drug effects
  • Chitosan/chemistry
  • Drug Carriers/chemistry
  • Drug Compounding
  • Fibroblasts
  • Male
  • Nanostructures/chemistry
  • Oleic Acid/chemistry
  • Rats
  • Rats, Wistar
  • Rheology
  • Silver Sulfadiazine/chemistry
  • Skin/injuries
  • Wounds and Injuries/drug therapy
  • alpha-Tocopherol/chemistry

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