Association of antigen-processing machinery and HLA antigen phenotype of melanoma cells with survival in American Joint Committee on Cancer stage III and IV melanoma patients

Andrea Anichini, Roberta Mortarini, Daisuke Nonaka, Alessandra Molla, Claudia Vegetti, Elisabetta Montaldi, Xinhui Wang, Soldano Ferrone

Research output: Contribution to journalArticlepeer-review

Abstract

Because changes in the expression level of antigen-processing machinery (APM) components and HLA class I and II antigens in melanoma cells are expected to affect their interactions with the immune system of the host, we assessed the clinical relevance of quantitative variations in the expression of these molecules in melanoma lesions. Short-term (2- microglobulin and HLA class II antigen expression were significantly associated with patients' survival. This evidence was corroborated by the immunohistochemical analysis for HLA class II antigen expression of melanoma lesions from an unrelated group of 52 AJCC stage III and IV patients. These results suggest that quantitative variations in APM component and HLA expression in melanoma lesions from AJCC stage III and IV patients may have an effect on the clinical course of the disease.

Original languageEnglish
Pages (from-to)6405-6411
Number of pages7
JournalCancer Research
Volume66
Issue number12
DOIs
Publication statusPublished - Jun 15 2006

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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