Association of Body Fat With Health-Related Quality of Life and Depression in Nonagenarians: The Mugello Study

Mugello Study Working Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: The association of body fat with health status and depression in the oldest old is still debated. The aim of this cross-sectional study is to investigate the association of body fat with health-related quality of life and depression in a sample of nonagenarians. Design: Data are from the Mugello study, a community-based project conducted in Italian older adults aged 90 years. Setting and participants: Total body fat was assessed by body impedance assessment. Participants were divided into 3 groups according to gender-specific tertiles of body fat percentage (BF%). Self-perceived mental and physical health status were assessed by the Mental Component Summary (MCS) and the Physical Component Summary (PCS) subscales derived from the 12-item Short Form Health Survey. Lower scores of MCS and PCS indicated poorer mental health and physical health status, respectively. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale, and a score ≥5 was used to identify participants with depression. Results: The mean age of 251 study participants was 92.5 years, and 173 (68.9%) were women. Participants were included in the low (n = 83), medium (n = 83), and high (n = 85) BF% groups. In the whole sample, mean scores at PCS progressively declined with the increasing BF% group (P =.004). This association was stronger in women, although no significant interaction was observed between the gender and BF% group (P =.63). No significant association between BF% and MCS was documented. Medium and high BF% were associated with a significantly higher probability of depression as compared with low BF% [odds ratio (OR) 2.15, 95% confidence interval (CI) 1.04-4.44, and OR 2.15, 95% CI 1.06-4.34, respectively]. This association was stronger in women, although no significant interaction was observed between gender and BF% group (P =.70). Conclusions and implications: High BF% is significantly positively associated with poor health-related quality of life and depression, underpinning the clinical relevance to test BF% in older adults. These associations appear to be stronger in women than in men, highlighting the need to investigate deep inside this gender discrepancy.

Original languageEnglish
JournalJournal of the American Medical Directors Association
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Adipose Tissue
Quality of Life
Depression
Health Status
Mental Health
Odds Ratio
Confidence Intervals
Health Surveys
Electric Impedance
Geriatrics
Cross-Sectional Studies

Keywords

  • Body fat percentage
  • depression
  • nonagenarians
  • physical activity

ASJC Scopus subject areas

  • Nursing(all)
  • Health Policy
  • Geriatrics and Gerontology

Cite this

@article{d2359e98d6174d05ae3470bc30c002b6,
title = "Association of Body Fat With Health-Related Quality of Life and Depression in Nonagenarians: The Mugello Study",
abstract = "Objectives: The association of body fat with health status and depression in the oldest old is still debated. The aim of this cross-sectional study is to investigate the association of body fat with health-related quality of life and depression in a sample of nonagenarians. Design: Data are from the Mugello study, a community-based project conducted in Italian older adults aged 90 years. Setting and participants: Total body fat was assessed by body impedance assessment. Participants were divided into 3 groups according to gender-specific tertiles of body fat percentage (BF{\%}). Self-perceived mental and physical health status were assessed by the Mental Component Summary (MCS) and the Physical Component Summary (PCS) subscales derived from the 12-item Short Form Health Survey. Lower scores of MCS and PCS indicated poorer mental health and physical health status, respectively. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale, and a score ≥5 was used to identify participants with depression. Results: The mean age of 251 study participants was 92.5 years, and 173 (68.9{\%}) were women. Participants were included in the low (n = 83), medium (n = 83), and high (n = 85) BF{\%} groups. In the whole sample, mean scores at PCS progressively declined with the increasing BF{\%} group (P =.004). This association was stronger in women, although no significant interaction was observed between the gender and BF{\%} group (P =.63). No significant association between BF{\%} and MCS was documented. Medium and high BF{\%} were associated with a significantly higher probability of depression as compared with low BF{\%} [odds ratio (OR) 2.15, 95{\%} confidence interval (CI) 1.04-4.44, and OR 2.15, 95{\%} CI 1.06-4.34, respectively]. This association was stronger in women, although no significant interaction was observed between gender and BF{\%} group (P =.70). Conclusions and implications: High BF{\%} is significantly positively associated with poor health-related quality of life and depression, underpinning the clinical relevance to test BF{\%} in older adults. These associations appear to be stronger in women than in men, highlighting the need to investigate deep inside this gender discrepancy.",
keywords = "Body fat percentage, depression, nonagenarians, physical activity",
author = "Silvia Giovannini and Claudio Macchi and Rossella Liperoti and Alice Laudisio and Daniele Coraci and Claudia Loreti and Federica Vannetti and Graziano Onder and Luca Padua and {Mugello Study Working Group} and Guglielmo Bonaccorsi and Roberta Boni and Chiara CastagnolI and Francesca Cecchi and Francesca Cesari and Francesco Epifani and Roberta Frandi and Betti Giusti and Luisi, {Maria Luisa Eliana} and Rossella Marcucci and Raffaello Molino-Lova and Anita Paperini and Lorenzo Razzolini and Francesco Sofi and Nona Turcan and Debora Valecchi",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jamda.2019.01.128",
language = "English",
journal = "Journal of the American Medical Directors Association",
issn = "1525-8610",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Association of Body Fat With Health-Related Quality of Life and Depression in Nonagenarians

T2 - The Mugello Study

AU - Giovannini, Silvia

AU - Macchi, Claudio

AU - Liperoti, Rossella

AU - Laudisio, Alice

AU - Coraci, Daniele

AU - Loreti, Claudia

AU - Vannetti, Federica

AU - Onder, Graziano

AU - Padua, Luca

AU - Mugello Study Working Group

AU - Bonaccorsi, Guglielmo

AU - Boni, Roberta

AU - CastagnolI, Chiara

AU - Cecchi, Francesca

AU - Cesari, Francesca

AU - Epifani, Francesco

AU - Frandi, Roberta

AU - Giusti, Betti

AU - Luisi, Maria Luisa Eliana

AU - Marcucci, Rossella

AU - Molino-Lova, Raffaello

AU - Paperini, Anita

AU - Razzolini, Lorenzo

AU - Sofi, Francesco

AU - Turcan, Nona

AU - Valecchi, Debora

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: The association of body fat with health status and depression in the oldest old is still debated. The aim of this cross-sectional study is to investigate the association of body fat with health-related quality of life and depression in a sample of nonagenarians. Design: Data are from the Mugello study, a community-based project conducted in Italian older adults aged 90 years. Setting and participants: Total body fat was assessed by body impedance assessment. Participants were divided into 3 groups according to gender-specific tertiles of body fat percentage (BF%). Self-perceived mental and physical health status were assessed by the Mental Component Summary (MCS) and the Physical Component Summary (PCS) subscales derived from the 12-item Short Form Health Survey. Lower scores of MCS and PCS indicated poorer mental health and physical health status, respectively. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale, and a score ≥5 was used to identify participants with depression. Results: The mean age of 251 study participants was 92.5 years, and 173 (68.9%) were women. Participants were included in the low (n = 83), medium (n = 83), and high (n = 85) BF% groups. In the whole sample, mean scores at PCS progressively declined with the increasing BF% group (P =.004). This association was stronger in women, although no significant interaction was observed between the gender and BF% group (P =.63). No significant association between BF% and MCS was documented. Medium and high BF% were associated with a significantly higher probability of depression as compared with low BF% [odds ratio (OR) 2.15, 95% confidence interval (CI) 1.04-4.44, and OR 2.15, 95% CI 1.06-4.34, respectively]. This association was stronger in women, although no significant interaction was observed between gender and BF% group (P =.70). Conclusions and implications: High BF% is significantly positively associated with poor health-related quality of life and depression, underpinning the clinical relevance to test BF% in older adults. These associations appear to be stronger in women than in men, highlighting the need to investigate deep inside this gender discrepancy.

AB - Objectives: The association of body fat with health status and depression in the oldest old is still debated. The aim of this cross-sectional study is to investigate the association of body fat with health-related quality of life and depression in a sample of nonagenarians. Design: Data are from the Mugello study, a community-based project conducted in Italian older adults aged 90 years. Setting and participants: Total body fat was assessed by body impedance assessment. Participants were divided into 3 groups according to gender-specific tertiles of body fat percentage (BF%). Self-perceived mental and physical health status were assessed by the Mental Component Summary (MCS) and the Physical Component Summary (PCS) subscales derived from the 12-item Short Form Health Survey. Lower scores of MCS and PCS indicated poorer mental health and physical health status, respectively. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale, and a score ≥5 was used to identify participants with depression. Results: The mean age of 251 study participants was 92.5 years, and 173 (68.9%) were women. Participants were included in the low (n = 83), medium (n = 83), and high (n = 85) BF% groups. In the whole sample, mean scores at PCS progressively declined with the increasing BF% group (P =.004). This association was stronger in women, although no significant interaction was observed between the gender and BF% group (P =.63). No significant association between BF% and MCS was documented. Medium and high BF% were associated with a significantly higher probability of depression as compared with low BF% [odds ratio (OR) 2.15, 95% confidence interval (CI) 1.04-4.44, and OR 2.15, 95% CI 1.06-4.34, respectively]. This association was stronger in women, although no significant interaction was observed between gender and BF% group (P =.70). Conclusions and implications: High BF% is significantly positively associated with poor health-related quality of life and depression, underpinning the clinical relevance to test BF% in older adults. These associations appear to be stronger in women than in men, highlighting the need to investigate deep inside this gender discrepancy.

KW - Body fat percentage

KW - depression

KW - nonagenarians

KW - physical activity

UR - http://www.scopus.com/inward/record.url?scp=85062358572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062358572&partnerID=8YFLogxK

U2 - 10.1016/j.jamda.2019.01.128

DO - 10.1016/j.jamda.2019.01.128

M3 - Article

AN - SCOPUS:85062358572

JO - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

SN - 1525-8610

ER -