Association of c-erbB-2 expression and S-phase fraction in the prognosis of node positive breast cancer

R. Anbazhagan, R. D. Gelber, R. Bettelheim, A. Goldhirsch, B. A. Gusterson

Research output: Contribution to journalArticle

Abstract

An immunohistochemical study was performed on 211 primary breast carcinomas for c-erbB-2 expression. All patients had involvement of axillary lymph nodes and all were randomised onto one of the Ludwig Breast Cancer Trials I-IV between July l978 and August I981. c-erbB-2 overexpression significantly correlated with high S-phase fraction, four or more positive axillary nodes involved, estrogen receptor negative primaries, progesterone receptor negative primaries, high grade tumours and DNA aneuploidy. With a nine year median follow-up c-erbB-2 positive tumours had worse disease-free survival (p = 0.0002) and overall survival (p <0.0001). Multivariate analyses using proportional hazard regression models demonstrated that c-erbB-2 positivity continued to predict a poor outcome even when accounting for the effects of other prognostic factors.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalAnnals of Oncology
Volume2
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Hematology

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