Association of chromosome 12p genetic polymorphisms with lung adenocarcinoma risk and prognosis

Giacomo Manenti, Laura De Gregorio, Silvana Pilotti, F. Stefania Falvella, Matteo Incarbone, Fernando Ravagnani, Marco A. Pierotti, Tommaso A. Dragani

Research output: Contribution to journalArticle

Abstract

The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 219 healthy blood donor subjects for five polymorphic markers mapping in the putative region of interest. Three marker polymorphisms, located in a region spanning ~700 kb, were significantly associated with lung adenocarcinoma risk. Furthermore, polymorphisms in KRAS2 and PTHLH loci were also associated with tumor prognosis. These results suggest the existence of a human Pas1 homologous locus on chromosome 12p12.

Original languageEnglish
Pages (from-to)1917-1920
Number of pages4
JournalCarcinogenesis
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 1997

ASJC Scopus subject areas

  • Cancer Research

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