Association of chronic non-steroidal anti-inflammatory drugs use and cognitive decline in non-demented elderly patients admitted to a Geriatric Evaluation and Rehabilitation Unit

B. Bertozzi, P. Barbisoni, S. Franzoni, G. B. Frisoni, R. Rozzini, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

In a geriatric evaluation and rehabilitation unit (GERU), 258 elderly patients (M: 71, F: 187; mean age 77.4 ± 7.5) scoring 22 or more at Mini-Mental State Examination (MMSE) consecutively admitted were assessed in order to evaluate the effects of non-steroidal anti-inflammatory drugs (NSAID) chronic treatment on cognitive status in non-demented elderly patients. Sixty-six patients (25.6%) were considered chronic NSAID users. Patients chronically assuming NSAIDs showed a significantly higher MMSE score than non-users (26.9 ± 2.1 vs. 25.7 ± 2.5, P <0.0005). After controlling for potential confounders in a multivariate model, chronic NSAID use remained independently associated with MMSE score. The results support a positive association between chronic NSAID use and cognitive function in non-demented elderly patients. Randomized controlled trials will be needed to definitively prove this beneficial effect.

Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalArchives of Gerontology and Geriatrics
Volume23
Issue number1
DOIs
Publication statusPublished - Jul 1996

Keywords

  • Co-morbidity
  • Cognitive decline
  • Non-steroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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