Association of Cytogenetic Abnormalities with Detection of BCR-ABL Fusion Transcripts in Children with T-Lineage Lymphoproliferative Diseases (T-ALL and T-NHL)

Luca Lo Nigro, Laura Sainati, Elena Mirabile, Marina Lanciotti, Amelia Poli, Anna Leszl, Giuseppe Basso

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.

Original languageEnglish
Pages (from-to)278-280
Number of pages3
JournalPediatric Blood and Cancer
Volume42
Issue number3
Publication statusPublished - Mar 2004

Fingerprint

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Lymphoproliferative Disorders
Chromosome Aberrations
Philadelphia Chromosome
Residual Neoplasm
Cytogenetics
Clone Cells
Chromosomes
T-Lymphocytes

Keywords

  • Acute lymphoblastic leukemia
  • BCR-ABL
  • Child
  • T-lineage

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Association of Cytogenetic Abnormalities with Detection of BCR-ABL Fusion Transcripts in Children with T-Lineage Lymphoproliferative Diseases (T-ALL and T-NHL). / Nigro, Luca Lo; Sainati, Laura; Mirabile, Elena; Lanciotti, Marina; Poli, Amelia; Leszl, Anna; Basso, Giuseppe.

In: Pediatric Blood and Cancer, Vol. 42, No. 3, 03.2004, p. 278-280.

Research output: Contribution to journalArticle

Nigro, Luca Lo ; Sainati, Laura ; Mirabile, Elena ; Lanciotti, Marina ; Poli, Amelia ; Leszl, Anna ; Basso, Giuseppe. / Association of Cytogenetic Abnormalities with Detection of BCR-ABL Fusion Transcripts in Children with T-Lineage Lymphoproliferative Diseases (T-ALL and T-NHL). In: Pediatric Blood and Cancer. 2004 ; Vol. 42, No. 3. pp. 278-280.
@article{a740c5e843e240518abd69a6baa898dd,
title = "Association of Cytogenetic Abnormalities with Detection of BCR-ABL Fusion Transcripts in Children with T-Lineage Lymphoproliferative Diseases (T-ALL and T-NHL)",
abstract = "Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.",
keywords = "Acute lymphoblastic leukemia, BCR-ABL, Child, T-lineage",
author = "Nigro, {Luca Lo} and Laura Sainati and Elena Mirabile and Marina Lanciotti and Amelia Poli and Anna Leszl and Giuseppe Basso",
year = "2004",
month = "3",
language = "English",
volume = "42",
pages = "278--280",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Association of Cytogenetic Abnormalities with Detection of BCR-ABL Fusion Transcripts in Children with T-Lineage Lymphoproliferative Diseases (T-ALL and T-NHL)

AU - Nigro, Luca Lo

AU - Sainati, Laura

AU - Mirabile, Elena

AU - Lanciotti, Marina

AU - Poli, Amelia

AU - Leszl, Anna

AU - Basso, Giuseppe

PY - 2004/3

Y1 - 2004/3

N2 - Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.

AB - Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.

KW - Acute lymphoblastic leukemia

KW - BCR-ABL

KW - Child

KW - T-lineage

UR - http://www.scopus.com/inward/record.url?scp=1242339689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242339689&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 278

EP - 280

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 3

ER -