Association of Cytogenetic Abnormalities with Detection of BCR-ABL Fusion Transcripts in Children with T-Lineage Lymphoproliferative Diseases (T-ALL and T-NHL)

Luca Lo Nigro, Laura Sainati, Elena Mirabile, Marina Lanciotti, Amelia Poli, Anna Leszl, Giuseppe Basso

Research output: Contribution to journalArticle

Abstract

Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.

Original languageEnglish
Pages (from-to)278-280
Number of pages3
JournalPediatric Blood and Cancer
Volume42
Issue number3
Publication statusPublished - Mar 2004

Keywords

  • Acute lymphoblastic leukemia
  • BCR-ABL
  • Child
  • T-lineage

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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