Association of early-onset Alzheimer's disease with an interleukin-1α gene polymorphism

Luigi M E Grimaldi, Valeria M. Casadei, Cinzia Ferri, Fabrizio Veglia, Federico Licastro, Giorgio Annoni, Ida Biunno, Gianluca De Bellis, Sandro Sorbi, Claudio Mariani, Nicola Canal, W. Sue T Griffin, Massimo Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Overexpression of the pluripotent cytokine interleukin-1 (IL-1) by microglial cells correlates with formation of neuritic β-amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms in the genes coding for the IL-1α, IL-1β, and IL-1 receptor antagonist cytokines, and tested their association with the occurrence and age at onset of sporadic AD. We found a strong association between the IL-1A T/T genotype and AD onset before 65 years of age (odds ratio, 4.86), with carriers of this genotype showing an onset of disease 9 years earlier than IL-1A C/C carriers. A weaker association with the age at onset was also shown for the IL-1B and IL-1RN genes. These data suggest either a direct effect of the IL-1 gene family, mainly IL-1A, on the clinical onset of AD, or a linkage dysequilibrium with an unknown locus relevant to AD on chromosome 2.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalAnnals of Neurology
Volume47
Issue number3
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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