Association of early-onset Alzheimer's disease with an interleukin-1α gene polymorphism

Luigi M E Grimaldi, Valeria M. Casadei, Cinzia Ferri, Fabrizio Veglia, Federico Licastro, Giorgio Annoni, Ida Biunno, Gianluca De Bellis, Sandro Sorbi, Claudio Mariani, Nicola Canal, W. Sue T Griffin, Massimo Franceschi

Research output: Contribution to journalArticle

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Abstract

Overexpression of the pluripotent cytokine interleukin-1 (IL-1) by microglial cells correlates with formation of neuritic β-amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms in the genes coding for the IL-1α, IL-1β, and IL-1 receptor antagonist cytokines, and tested their association with the occurrence and age at onset of sporadic AD. We found a strong association between the IL-1A T/T genotype and AD onset before 65 years of age (odds ratio, 4.86), with carriers of this genotype showing an onset of disease 9 years earlier than IL-1A C/C carriers. A weaker association with the age at onset was also shown for the IL-1B and IL-1RN genes. These data suggest either a direct effect of the IL-1 gene family, mainly IL-1A, on the clinical onset of AD, or a linkage dysequilibrium with an unknown locus relevant to AD on chromosome 2.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalAnnals of Neurology
Volume47
Issue number3
DOIs
Publication statusPublished - 2000

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Interleukin-1
Alzheimer Disease
Genes
Amyloid Plaques
Age of Onset
Genotype
Cytokines
Chromosomes, Human, Pair 2
Interleukin-1 Receptors
Odds Ratio

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Association of early-onset Alzheimer's disease with an interleukin-1α gene polymorphism. / Grimaldi, Luigi M E; Casadei, Valeria M.; Ferri, Cinzia; Veglia, Fabrizio; Licastro, Federico; Annoni, Giorgio; Biunno, Ida; De Bellis, Gianluca; Sorbi, Sandro; Mariani, Claudio; Canal, Nicola; Griffin, W. Sue T; Franceschi, Massimo.

In: Annals of Neurology, Vol. 47, No. 3, 2000, p. 361-365.

Research output: Contribution to journalArticle

Grimaldi, LME, Casadei, VM, Ferri, C, Veglia, F, Licastro, F, Annoni, G, Biunno, I, De Bellis, G, Sorbi, S, Mariani, C, Canal, N, Griffin, WST & Franceschi, M 2000, 'Association of early-onset Alzheimer's disease with an interleukin-1α gene polymorphism', Annals of Neurology, vol. 47, no. 3, pp. 361-365. https://doi.org/10.1002/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO;2-N
Grimaldi, Luigi M E ; Casadei, Valeria M. ; Ferri, Cinzia ; Veglia, Fabrizio ; Licastro, Federico ; Annoni, Giorgio ; Biunno, Ida ; De Bellis, Gianluca ; Sorbi, Sandro ; Mariani, Claudio ; Canal, Nicola ; Griffin, W. Sue T ; Franceschi, Massimo. / Association of early-onset Alzheimer's disease with an interleukin-1α gene polymorphism. In: Annals of Neurology. 2000 ; Vol. 47, No. 3. pp. 361-365.
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